Trial reportBMC gastroenterology2010
Study protocol: population screening for colorectal cancer by colonoscopy or CT colonography: a randomized controlled trial.
Trial report in BMC gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Near-infrared fluorescence imaging for sentinel lymph node identification in colon cancer: a prospective single-center study and systematic review with meta-analysis.Techniques in coloproctology · 2019Pooled it
- Guideline
- Computer tomography colonography participation and yield in patients under surveillance for 6-9 mm polyps in a population-based screening trial.European radiology · 2016Trial
- CT-Colonography vs. Colonoscopy for Detection of High-Risk Sessile Serrated Polyps.The American journal of gastroenterology · 2016Trial
- Face-to-face vs telephone pre-colonoscopy consultation in colorectal cancer screening; a randomised trial.British journal of cancer · 2012Trial
- A randomized double-blind placebo-controlled trial to evaluate the value of a single bolus intravenous alfentanil in CT colonography.BMC gastroenterology · 2011Trial
- Developing a New Stool Test for Colorectal Cancer Screening, the multitargetFIT (mtFIT).Digestive diseases and sciences · 2025Article
- Prevalence of neoplasia at colonoscopy among testicular cancer survivors treated with platinum-based chemotherapy.International journal of cancer · 2024Article
- Methodological Quality of PROMs in Psychosocial Consequences of Colorectal Cancer Screening: A Systematic Review.Patient related outcome measures · 2023Review
- Can Computed Tomography Colonography Replace Optical Colonoscopy in Detecting Colorectal Lesions?: State of the Art.Clinical endoscopy · 2022Review
- Individualized faecal immunochemical test cut-off based on age and sex in colorectal cancer screening.Preventive medicine reports · 2021Article
- Proteins in stool as biomarkers for non-invasive detection of colorectal adenomas with high risk of progression.The Journal of pathology · 2020Article
- Multitarget Stool DNA Test Performance in an Average-Risk Colorectal Cancer Screening Population.The American journal of gastroenterology · 2019Article
- Perioperative PET/CT lymphoscintigraphy and fluorescent real-time imaging for sentinel lymph node mapping in early staged colon cancer.European journal of nuclear medicine and molecular imaging · 2019Article
- Fecal immunochemical test-based colorectal cancer screening: The gender dilemma.United European gastroenterology journal · 2017Article
- CT colonography for population screening of colorectal cancer: hints from European trials.The British journal of radiology · 2016Review
- Burden of waiting for surveillance CT colonography in patients with screen-detected 6-9 mm polyps.European radiology · 2016Article
- Smoking status informs about the risk of advanced serrated polyps in a screening population.Endoscopy international open · 2016Article
- Defining the Risk of Small Polyps: Potential Value of CTC.The American journal of gastroenterology · 2015Article
- Evolution of Screen-Detected Small (6-9 mm) Polyps After a 3-Year Surveillance Interval: Assessment of Growth With CT Colonography Compared With Histopathology.The American journal of gastroenterology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundColorectal cancer (CRC) is the second most prevalent type of cancer in Europe. Early detection and removal of CRC or its precursor lesions by population screening can reduce mortality. Colonoscopy and computed tomography colonography (CT colonography) are highly accurate exams and screening options that examine the entire colon. The success of screening depends on the participation rate. We designed a randomized trial to compare the uptake, yield and costs of direct colonoscopy population screening, using either a telephone consultation or a consultation at the outpatient clinic, versus CT colonography first, with colonoscopy in CT colonography positives. METHODS AND
design7,500 persons between 50 and 75 years will be randomly selected from the electronic database of the municipal administration registration and will receive an invitation to participate in either CT colonography (2,500 persons) or colonoscopy (5,000 persons) screening. Those invited for colonoscopy screening will be randomized to a prior consultation either by telephone or a visit at the outpatient clinic. All CT colonography invitees will have a prior consultation by telephone. Invitees are instructed to consult their general practitioner and not to participate in screening if they have symptoms suggestive for CRC. After providing informed consent, participants will be scheduled for the screening procedure. The primary outcome measure of this study is the participation rate. Secondary outcomes are the diagnostic yield, the expected and perceived burden of the screening test, level of informed choice and cost-effectiveness of both screening methods. DISCUSSION: This study will provide further evidence to enable decision making in population screening for colorectal cancer.
trial registrationDutch trial register: NTR1829.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.