ArticleDiagnostic pathology2010
Combined evaluation of bone marrow aspirate and biopsy is superior in the prognosis of multiple myeloma.
Article in Diagnostic pathology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- The Challenge of Determining the Etiology of Encephalopathy in an Elderly Patient.Clinical case reports · 2026Article
- Impact of the plasma cell quantification method on the International Myeloma Working Group diagnostic criteria for MGUS/SMM.Haematologica · 2026Article
- Circulating Plasma Cells as a Minimally Invasive Adjunct to Bone Marrow Aspirates for Genetic Analysis of ER Stress and Autophagy in Multiple Myeloma: A Feasibility Study.Biomedicines · 2026Article
- Comparative Diagnostic Performance of Flow Cytometry, Aspiration, and Biopsy with Immunohistochemistry in Plasma Cell Neoplasms.International journal of hematology-oncology and stem cell research · 2025Article
- Prognosis of multiple myeloma patients based on histopathological evaluation of bone marrow.Caspian journal of internal medicine · 2025Article
- Comparison of plasma cell bone marrow counts by different methods in patients diagnosed with plasma cell disorders.Hematology, transfusion and cell therapy · 2024Article
- Advances in estimating plasma cells in bone marrow: A comprehensive method review.African journal of laboratory medicine · 2024Review
- Deep Learning Accurately Quantifies Plasma Cell Percentages on CD138-Stained Bone Marrow Samples.Journal of pathology informatics · 2022Article
- Serum BCMA levels predict outcomes in MGUS and smoldering myeloma patients.Blood cancer journal · 2021Article
- Biological properties of bone marrow plasma cells influence their recovery in aspirate specimens: impact on classification of plasma cell disorders and potential bias to evaluation of treatment response.Annals of hematology · 2020Article
- Dynamic Profiling of Antitumor Activity of CAR T Cells Using Micropatterned Tumor Arrays.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Survival rate of multiple myeloma patients in Indonesia: A retrospective study in multiple myeloma at a single institution.Annals of medicine and surgery (2012) · 2019Article
- Discrepancies between the percentage of plasma cells in bone marrow aspiration and BM biopsy: Impact on the revised IMWG diagnostic criteria of multiple myeloma.Blood cancer journal · 2017Article
- Aggressive multiple myeloma with unusual morphology.Turkish journal of haematology : official journal of Turkish Society of Haematology · 2014Article
- Comparative evaluation of bone marrow aspirate with trephine biopsy in hematological disorders and determination of optimum trephine length in lymphoma infiltration.Mediterranean journal of hematology and infectious diseases · 2014Article
- Second-Generation Tyrosine Kinase Inhibitors (Tki) as Salvage Therapy for Resistant or Intolerant Patients to Prior TKIs.Mediterranean journal of hematology and infectious diseases · 2014Review
- Article
- Utility of a column-free cell sorting system for separation of plasma cells in multiple myeloma FISH testing in clinical laboratories.International journal of hematology · 2012Article
- Comparison of bone marrow aspiration cytology with bone marrow trephine biopsy histopathology: An observational study.Journal of laboratory physiciansArticle
- Role of CD138, CD56, and light chain immunohistochemistry in suspected and diagnosed plasma cell myeloma: A prospective study.South Asian journal of cancerArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
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Abstract
backgroundEstimation of plasma cell infiltrates in bone marrow aspirates (BMA) and bone marrow biopsy (BMB) is a standard method in the diagnosis and monitoring of multiple myeloma (MM). Plasma cell fraction in the bone marrow is therefore critical for the classification and optimal clinical management of patients with plasma cell dyscrasias. The aim of the study was to compare the percentage of plasma cells obtained by both methods with the patient clinical parameters and survival.
methodsThis retrospective study included BMA and BMB of 59 MM patients. The conventional differential count was determined in BMA to estimate the percentage and cytologic grade of plasma cells. The pattern of neoplastic infiltration and percentage of plasma cells were estimated on CD138 immunostained BMB slides microscopically and by computer-assisted image analysis (CIA).
resultsSignificantly higher values of plasma cell infiltrates were observed in pathologist (47.7 +/- 24.8) and CIA (44.1 +/- 30.6) reports in comparison with cytologist analysis (30.6 +/- 17.1; P < 0.001 and P < 0.0048, respectively). BMB assessment by pathologist counting and using CIA showed strongest correlation (r = 0.8; P < 0.0001). Correlation was also observed between the pathologist and cytologist counts (r = 0.321; P = 0.015) as well as comparing the percentage of plasma cells in BMA and CIA (r = 0.27; P = 0.05). Patients with clinical stage I/II had a significantly lower CIA plasma cell count than those with clinical stage III (P = 0.008). Overall survival was shorter in patients with more than 25% of atypical plasma cell morphology estimated in BMA (P = 0.05) and a higher percentage of tumor cell infiltrates estimated by the pathologist and CIA (P = 0.0341 and P = 0.013, respectively).
conclusionStudy results suggested the combined analyses to be useful as a routine procedure to achieve more accurate and informative diagnostic data.
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