ArticleDiabetology & metabolic syndrome2010
Association between insulin resistance and c-reactive protein among Peruvian adults.
Article in Diabetology & metabolic syndrome, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 81 citations in OpenAlex.
- Association between estimated glucose disposal rate and testosterone deficiency in male patients with type 2 diabetes mellitus.BMC endocrine disorders · 2025Article
- Understanding the link between insulin resistance and cognition: a cross-sectional study conducted in an urban, South Indian cohort.Acta diabetologica · 2025Article
- Whole body and hematopoietic cell-specific deletion of G-protein coupled receptor 65 (GPR65) improves insulin sensitivity in diet-induced obese mice.Molecular metabolism · 2025Article
- Physical activity affects DNA methylation-derived inflammation markers in a community-based Parkinson's disease study.Brain, behavior, & immunity - health · 2025Article
- Prediction of insulin resistance using multiple adaptive regression spline in Chinese women.Endocrine journal · 2025Article
- Insulin Resistance: Understanding the Cognitive Implications.Indian journal of psychological medicine · 2025Article
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- Association between weight-adjusted waist index and testosterone deficiency in adult American men: findings from the national health and nutrition examination survey 2013-2016.BMC public health · 2024Article
- Changes in insulin resistance following antidepressant treatment mediate response in major depressive disorder.Journal of psychopharmacology (Oxford, England) · 2023Article
- Disease-associated metabolic pathways affected by heavy metals and metalloid.Toxicology reports · 2023Review
- Zinc Supplementation Improved Neuropeptide Y, Nesfatin-1, Leptin, C-reactive protein, and HOMA-IR of Diet-Induced Obese Rats.Biological trace element research · 2022Article
- C-reactive protein in adult Samoans: Population variation and physiological correlates.American journal of human biology : the official journal of the Human Biology Council · 2022Article
- Insulin sensitivity variations in apparently healthy Arab male subjects: correlation with insulin and C peptide.BMJ open diabetes research & care · 2021Article
- Weight reduction ameliorates inflammatory cytokines, adipocytokines and endothelial dysfunction biomarkers among Saudi patients with type 2 diabetes.African health sciences · 2020Article
- SERPINE-1 Gene Methylation and Protein as Molecular Predictors of Laparoscopic Sleeve Gastrectomy Outcome.Obesity surgery · 2020Article
- Article
- Causal Effects of Overall and Abdominal Obesity on Insulin Resistance and the Risk of Type 2 Diabetes Mellitus: A Two-Sample Mendelian Randomization Study.Frontiers in genetics · 2020Article
- Effects of adiposity and metabolic dysfunction on cognition: A review.Physiology & behavior · 2019Review
- Article
- Prevalence of vitamin D deficiency and its association with metabolic derangements among children with obesity.BMC pediatrics · 2019Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveInsulin resistance (IR), a reduced physiological response of peripheral tissues to the action of insulin, is one of the major causes of type 2 diabetes. We sought to evaluate the relationship between serum C-reactive protein (CRP), a marker of systemic inflammation, and prevalence of IR among Peruvian adults.
methodsThis population based study of 1,525 individuals (569 men and 956 women; mean age 39 years old) was conducted among residents in Lima and Callao, Peru. Fasting plasma glucose, insulin, and CRP concentrations were measured using standard approaches. Insulin resistance was assessed using the homeostasis model (HOMA-IR). Categories of CRP were defined by the following tertiles: <0.81 mg/l, 0.81-2.53 mg/l, and >2.53 mg/l. Logistic regression procedures were employed to estimate odds ratios (OR) and 95% confidence intervals (CI).
resultsElevated CRP were significantly associated with increased mean fasting insulin and mean HOMA-IR concentrations (p < 0.001). Women with CRP concentration >2.53 mg/l (upper tertile) had a 2.18-fold increased risk of IR (OR = 2.18 95% CI 1.51-3.16) as compared with those in the lowest tertile (<0.81 mg/l). Among men, those in the upper tertile had a 2.54-fold increased risk of IR (OR = 2.54 95% CI 1.54-4.20) as compared with those in the lowest tertile.
conclusionOur observations among Peruvians suggest that chronic systemic inflammation, as evidenced by elevated CRP, may be of etiologic importance in insulin resistance and diabetes.
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Registered trials
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