ArticleNeurogastroenterology and motility2010
Inhibitory neuromuscular transmission to ileal longitudinal muscle predominates in neonatal guinea pigs.
Article in Neurogastroenterology and motility, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- Changes in murine anorectum signaling across the life course.Neurogastroenterology and motility · 2018Article
- Changes in Nicotinic Neurotransmission during Enteric Nervous System Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Targeted gene delivery to the enteric nervous system using AAV: a comparison across serotypes and capsid mutants.Molecular therapy : the journal of the American Society of Gene Therapy · 2015Article
- Development and developmental disorders of the enteric nervous system.Nature reviews. Gastroenterology & hepatology · 2013Review
- Myenteric neurons of the mouse small intestine undergo significant electrophysiological and morphological changes during postnatal development.The Journal of physiology · 2012Article
- Postnatal development of the serotonin signaling system in the mucosa of the guinea pig ileum.Neurogastroenterology and motility · 2011Article
- Boron-doped diamond nano/microelectrodes for biosensing and in vitro measurements.Frontiers in bioscience (Scholar edition) · 2011Review
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundInhibitory neurotransmission to the longitudinal muscle is more prominent in the neonatal than in the adult guinea pig ileum.
methodsInhibitory neuromuscular transmission was investigated using in vitro ileal longitudinal muscle myenteric plexus (LMMP) preparations made from neonatal (< or =48 h postnatal) and adult ( approximately 4 weeks postnatal) guinea pigs. KEY
resultsAmperometric measurements of nicotine-induced nitric oxide (NO) release (measured as an oxidation current) from myenteric ganglia revealed larger currents in neonatal (379 +/- 24 pA) vs adult (119 +/- 39 pA, P < 0.05) tissues. Nicotine-induced oxidation currents were blocked by the nitric oxide synthase (NOS) inhibitor, nitro-l-arginine (NLA, 100 micromol L(-1)). Nicotine-induced, NLA-sensitive oxidation currents could be detected in the tertiary plexus of neonatal but not adult tissues. Immunohistochemistry demonstrated stronger NOS immunoreactivity in neonatal compared with adult myenteric ganglia. Western blot studies revealed higher levels of NOS in neonatal compared with adult LMMP. Cell counts revealed that the total number of myenteric neurons in the small intestine was greater in adults than in neonatal guinea pigs, however, the ratio of NOS : Calbindin neurons was significantly higher in neonatal compared with adult tissues. CONCLUSIONS & INFERENCES: Nitric oxide signaling to the longitudinal muscle is stronger in neonatal compared with adult guinea pig ileum. Nitric oxide synthase-containing neurons are diluted postnatally by cholinergic and other, as yet unidentified neuronal subtypes.
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