ArticlePhysical review. E, Statistical, nonlinear, and soft matter physics2010
Spontaneous oscillations, signal amplification, and synchronization in a model of active hair bundle mechanics.
Article in Physical review. E, Statistical, nonlinear, and soft matter physics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Complex dynamics of hair bundle of auditory nervous system (II): forced oscillations related to two cases of steady state.Cognitive neurodynamics · 2022Article
- Active Biomechanics of Sensory Hair Bundles.Cold Spring Harbor perspectives in medicine · 2019Review
- Friction from Transduction Channels' Gating Affects Spontaneous Hair-Bundle Oscillations.Biophysical journal · 2018Article
- Frequency sensitivity in mammalian hearing from a fundamental nonlinear physics model of the inner ear.Scientific reports · 2017Article
- Identification of Bifurcations from Observations of Noisy Biological Oscillators.Biophysical journal · 2016Article
- Voltage-Mediated Control of Spontaneous Bundle Oscillations in Saccular Hair Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Mechanical amplification exhibited by quiescent saccular hair bundles.Biophysical journal · 2015Article
- Low frequency entrainment of oscillatory bursts in hair cells.Biophysical journal · 2013Article
- Phase slips in oscillatory hair bundles.Physical review letters · 2013Article
- Mechanical overstimulation of hair bundles: suppression and recovery of active motility.PloS one · 2013Article
- Dynamics of freely oscillating and coupled hair cell bundles under mechanical deflection.Biophysical journal · 2012Article
- Spontaneous voltage oscillations and response dynamics of a Hodgkin-Huxley type model of sensory hair cells.Journal of mathematical neuroscience · 2011Article
- Multiple-timescale dynamics underlying spontaneous oscillations of saccular hair bundles.Biophysical journal · 2011Article
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2 authors.
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Abstract
We study spontaneous dynamics and signal transduction in a model of active hair bundle mechanics of sensory hair cells. The hair bundle motion is subjected to internal noise resulted from thermal fluctuations and stochastic dynamics of mechanoelectrical transduction ion channels. Similar to other studies we found that in the presence of noise the coherence of stochastic oscillations is maximal at a point on the bifurcation diagram away from the Andronov-Hopf bifurcation and is close to the point of maximum sensitivity of the system to weak periodic mechanical perturbations. Despite decoherent effect of noise the stochastic hair bundle oscillations can be synchronized by external periodic force of few pN amplitude in a finite range of control parameters. We then study effects of receptor potential oscillations on mechanics of the hair bundle and show that the hair bundle oscillations can be synchronized by oscillating receptor voltage. Moreover, using a linear model for the receptor potential we show that bidirectional coupling of the hair bundle and the receptor potential results in significant enhancement of the coherence of spontaneous oscillations and of the sensitivity to the external mechanical perturbations.
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