Evidence map›Paper›PMID 20481743›Full record

ArticlePhysical review. E, Statistical, nonlinear, and soft matter physics2010

Tightness of knots in a polymer chain.

Xiaozhong Zheng, Alexander Vologodskii

Abstract read
In one paragraph

Article in Physical review. E, Statistical, nonlinear, and soft matter physics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Effects of knot tightness at the molecular level.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Xiaozhong ZhengDepartment of Chemistry, New York University, New York, New York 10003, USA.
Alexander Vologodskii

Funding

DNA CATENANES AND TYPE II DNA TOPOISOMERASESR01GM054215 · NIGMS · NEW YORK UNIVERSITY · PI VOLOGODSKII, ALEXANDER V · 1996 to 2010
$2.8M
NIGMS NIH HHS R01 GM054215
6 · The paper itself

Abstract

It was predicted recently that sufficiently complex knots on a linear wormlike chain can have a metastable size, preventing their spontaneous expansion. We tested this prediction via computer simulations for 7(1) and 10(151) knots. We calculated the equilibrium distributions of knot size S for both knots. By using the umbrella sampling, we were able to obtain the distributions over a wide range of S values. The distributions were converted into the dependencies of the free energy on the knot size. The obtained free energy profiles have no pronounced local minima, so there are no metastable knot sizes for these knots. We also performed Brownian dynamics simulation of 7(1) knot relaxation that started from a very tight knot conformation. The simulation showed that knot expansion is a fast process compared to knot displacement along the chain contour by diffusion.

Indexed as

DNAMechanical PhenomenaModels, MolecularMolecular ConformationMonte Carlo MethodPolymersThermodynamicsDNAPolymers

Identifiers

PMID20481743
PMCPMC2874986

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.