ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2010
WWOX gene may contribute to progression of non-small-cell lung cancer (NSCLC).
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 28 citations in OpenAlex.
- Effect of WW Domain-Containing Oxidoreductase Gene Polymorphism on Clinicopathological Characteristics of Patients with EGFR Mutant Lung Adenocarcinoma in Taiwan.International journal of environmental research and public health · 2021Article
- Silencing of Wwox Increases Nuclear Import of Dvl proteins in Head and Neck Cancer.Journal of Cancer · 2020Article
- A p53/TIAF1/WWOX triad exerts cancer suppression but may cause brain protein aggregation due to p53/WWOX functional antagonism.Cell communication and signaling : CCS · 2019Article
- The correlation of the expressions of WWOX, LGR5 and vasohibin-1 in epithelial ovarian cancer and their clinical significance.International journal of clinical and experimental pathology · 2019Article
- Inhibition of miR-24 suppresses malignancy of human non-small cell lung cancer cells by targeting WWOX in vitro and in vivo.Thoracic cancer · 2018Article
- Modeling WWOX Loss of FunctionFrontiers in oncology · 2018Review
- Review
- Association of WWOX rs9926344 polymorphism with poor prognosis of hepatocellular carcinoma.Journal of Cancer · 2018Article
- Establishment of optimal regulatory network of colorectal cancer based on p42.3 protein.Saudi journal of biological sciences · 2017Article
- Decreased WWOX expression promotes angiogenesis in osteosarcoma.Oncotarget · 2017Article
- Establishment of apoptotic regulatory network for genetic markers of colorectal cancer.Saudi journal of biological sciences · 2017Article
- WWOX inhibits the invasion of lung cancer cells by downregulating RUNX2.Cancer gene therapy · 2016Article
- Adenovirus-delivered wwox inhibited lung cancer growth in vivo in a mouse model.Cancer gene therapy · 2016Article
- WWOX: a fragile tumor suppressor.Experimental biology and medicine (Maywood, N.J.) · 2015Review
- Regulation of cell signaling and apoptosis by tumor suppressor WWOX.Experimental biology and medicine (Maywood, N.J.) · 2015Review
- Epigenetic and genetic alterations affect the WWOX gene in head and neck squamous cell carcinoma.PloS one · 2015Article
- Diverse effect of WWOX overexpression in HT29 and SW480 colon cancer cell lines.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Impact of decitabine on immunohistochemistry expression of the putative tumor suppressor genes FHIT, WWOX, FUS1 and PTEN in clinical tumor samples.Clinical epigenetics · 2014Article
- Role of WWOX and NF-κB in lung cancer progression.Translational respiratory medicine · 2013Review
- Gene expression of WWOX, FHIT and p73 in acute lymphoblastic leukemia.Oncology letters · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lung cancer is the most common cause of cancer-related death worldwide and, like many other cancers, is affected by different genetic, epigenetic, and environmental factors. The WW domain-containing oxidoreductase (WWOX) gene is a tumor-suppressor gene located on chromosome 16q23.3-24.1, and it has been shown that it loses its function due to alterations in genetic and epigenetic mechanisms. The aim of this study is to investigate the relationship between lung cancer and WWOX gene. Tumor tissue samples, corresponding normal tissues, and blood samples obtained from 50 lung cancer patients were involved in the study. We analyzed methylation profile by methylation-specific PCR and mutations and polymorphisms by DNA sequencing. Methylation analysis showed that promoter hypermethylation was present in 38 of 50 (76%) patients. In addition, promoter region of WWOX gene of younger patients was more frequently methylated than older patients. Using DNA sequencing, we found four genetic alterations in WWOX gene. Two of them were germline mutations (Exon 4 and 7), and two of them were polymorphic (Exon 6 and 8). We found a new mutation in exon 7 (Arg-254-->Cys) which has not been described previously. The changes in the short-chain dehydrogenase domain of the protein caused by the genetic alterations may affect the function of the gene. We conclude that hypermethylation of WWOX gene promoter region and mutations in the gene might be related to lung carcinogenesis.
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