ArticleVeterinary research communications2010
LTR promoter activity of SRLV genotype E, strain Roccaverano.
Article in Veterinary research communications, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Permissiveness of different TMEM154 genotype cell lines to different SRLV genotypes/subtypes.Journal of virology · 2025Article
- Genetic Diversity of the LTR Region of Polish SRLVs and Its Impact on the Transcriptional Activity of Viral Promoters.Viruses · 2023Article
- The dUTPase of caprine arthritis-encephalitis virus negatively regulates interferon signaling pathway.Iranian journal of veterinary research · 2021Article
- Genotyping Based on the LTR Region of Small Ruminant Lentiviruses from Naturally Infected Sheep and Goats from Mexico.BioMed research international · 2019Article
- A new approach for Small Ruminant Lentivirus full genome characterization revealed the circulation of divergent strains.PloS one · 2019Article
- Maedi-Visna virus: current perspectives.Veterinary medicine (Auckland, N.Z.) · 2018Review
- Immunogenetics of small ruminant lentiviral infections.Viruses · 2014Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The highly divergent, small ruminant lentivirus (SRLV) genotype E Roccaverano strain has a full genome consisting of 8,418 nucleotides, which lack the entire dUTPase subunit of the pol gene, the vpr-like accessory gene, and the 71-bp repeat of the U3 region within the long terminal repeat (LTR). These deletions affect in reverse transcriptase fidelity in non-dividing cells (dUTPase and vpr-like) and in the regulation of viral replication. Surprisingly, this SRLV strain was able to replicate efficiently in non-dividing cells (i.e., blood-derived macrophages), while replication in fibroblastic-like cells was somewhat restricted. To evaluate whether this observation was due to the presence/absence of specific transcription factors within these fibroblasts, U3 transcriptional activity was measured in the different cell types and revealed that both fibroblasts and macrophages were able to activate the viral promoter in the same manner. Among the transcription factor-binding sites present within the U3 region, the highly conserved Ap4 tandem repeat was shown to be sufficient for LTR promoter activity.
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Registered trials
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