ReviewInternational journal of molecular sciences2010
Impact of dietary polyphenols on carbohydrate metabolism.
Review in International journal of molecular sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02486978 (Effects of Polyphenols Found in Pomegranate and Olives Food Supplements on Postprandial Blood Glucose in Vivo.), which is not on this map. Cited by 334 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Polyphenols Found in Pomegranate and Olives Food Supplements on Postprandial Blood Glucose in Vivo.
Who cites it
334 citing papers in PubMed, 4 syntheses or guidelines pooled it, 1,117 citations in OpenAlex.
- Serum lipids changes following cocoa intake in type 2 diabetes patients: a graded dose-response systematic review and meta-analysis of clinical trials.Acta diabetologica · 2025Pooled it
- Dietary Flavonoids and Human Cognition: A Meta-Analysis.Molecular nutrition & food research · 2022Pooled it
- 100% Fruit juice intake and cardiovascular risk: a systematic review and meta-analysis of prospective and randomised controlled studies.European journal of nutrition · 2021Pooled it
- Potential ofNutrients · 2020Pooled it
- Effects of Raspberry Leaf Tea Polyphenols on Postprandial Glucose and Insulin Responses in Healthy Adults.Nutrients · 2025Trial
- Trial
- Trial
- The impact of an acute high polyphenol, high fiber meal with and without aerobic exercise on metabolism in middle-aged and older adults: A pilot study.Physiological reports · 2025Trial
- Nutraceutical Properties of Thai Mulberry (Nutrients · 2024Trial
- Complementary Nutritional Improvements of Cereal-Based Products to Reduce Postprandial Glycemic Response.Nutrients · 2023Trial
- Blackcurrant (The British journal of nutrition · 2021Trial
- Both Isocarbohydrate and Hypercarbohydrate Fruit Preloads Curbed Postprandial Glycemic Excursion in Healthy Subjects.Nutrients · 2021Trial
- The Effects of a Functional Food Breakfast on Gluco-Regulation, Cognitive Performance, Mood, and Satiety in Adults.Nutrients · 2020Trial
- Guava (Nutrients · 2019Trial
- Indirect Chronic Effects of an Oleuropein-Rich Olive Leaf Extract on Sucrase-Isomaltase In Vitro and In Vivo.Nutrients · 2019Trial
- Article
- Echinatin Ameliorates Insulin Resistance and Hepatic Lipid Accumulation in db/db Mice.Biomedicines · 2026Article
- Foods as Modulators of GLP-1 Secretion.Nutrients · 2026Review
- The Nutraceutical Potential of Blackcurrant (Nutrients · 2026Review
- Antioxidant and Antidiabetic Activity of the Bulb Extract ofAntioxidants (Basel, Switzerland) · 2026Article
274 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyphenols, including flavonoids, phenolic acids, proanthocyanidins and resveratrol, are a large and heterogeneous group of phytochemicals in plant-based foods, such as tea, coffee, wine, cocoa, cereal grains, soy, fruits and berries. Growing evidence indicates that various dietary polyphenols may influence carbohydrate metabolism at many levels. In animal models and a limited number of human studies carried out so far, polyphenols and foods or beverages rich in polyphenols have attenuated postprandial glycemic responses and fasting hyperglycemia, and improved acute insulin secretion and insulin sensitivity. The possible mechanisms include inhibition of carbohydrate digestion and glucose absorption in the intestine, stimulation of insulin secretion from the pancreatic beta-cells, modulation of glucose release from the liver, activation of insulin receptors and glucose uptake in the insulin-sensitive tissues, and modulation of intracellular signalling pathways and gene expression. The positive effects of polyphenols on glucose homeostasis observed in a large number of in vitro and animal models are supported by epidemiological evidence on polyphenol-rich diets. To confirm the implications of polyphenol consumption for prevention of insulin resistance, metabolic syndrome and eventually type 2 diabetes, human trials with well-defined diets, controlled study designs and clinically relevant end-points together with holistic approaches e.g., systems biology profiling technologies are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.