ReviewInternational journal of molecular sciences2010
Tyrosinase-expressing neuronal cell line as in vitro model of Parkinson's disease.
Review in International journal of molecular sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 135 citations in OpenAlex.
- Potential Bioactive Function of Microbial Metabolites as Inhibitors of Tyrosinase: A Systematic Review.International journal of molecular sciences · 2026Pooled it
- tris-Schiff Base Derivatives Containing Flurbiprofen as Potential Tyrosinase Inhibitors: Synthesis, In Vitro Evaluation, Molecular Docking, DFT and Dynamics Simulations.Chemistry & biodiversity · 2026Article
- Lignans inFrontiers in plant science · 2026Article
- Neuromelanin-induced cellular stress and neurotoxicity in the pathogenesis of Parkinson's disease.Apoptosis : an international journal on programmed cell death · 2025Review
- Phytochemical analysis and enzyme inhibition of Origanum dictamnus L essential oil through in vitro and in silico methods.Scientific reports · 2025Article
- 7-Methoxybenzofuran-triazole tetheredRSC advances · 2025Article
- UVA-induced DNA damage and mutations in human melanocytes: relevance for melanoma mutations.Nucleic acids research · 2025Article
- Inhibition effects of Eucalyptus globules Labill. essential oil against tyrosinase.Scientific reports · 2025Article
- Unravelling the Role of Tyrosine and Tyrosine Hydroxylase in Parkinson's Disease: Exploring Nanoparticle-based Gene Therapies.CNS & neurological disorders drug targets · 2025Review
- Essential Oils of Tunisian Tetraclinis articulata (Vahl) Mast.: Chemical and Biological Insights.Chemistry & biodiversity · 2025Article
- Design, Synthesis, and Anti-Melanogenic Activity of 2-Mercaptomethylbenzo[Antioxidants (Basel, Switzerland) · 2024Article
- Exploring the Potential of Invasive SpeciesMarine drugs · 2024Article
- Selective dopaminergic neurotoxicity modulated by inherent cell-type specific neurobiology.Neurotoxicology · 2024Review
- Natural Polymer-Polyphenol Bioadhesive Coacervate with Stable Wet Adhesion, Antibacterial Activity, and On-Demand Detachment.Advanced healthcare materials · 2024Article
- Chemical Characterization and Biological Properties of Leguminous Honey.Antioxidants (Basel, Switzerland) · 2024Article
- Article
- Tyrosinase Inhibitors: A Perspective.Molecules (Basel, Switzerland) · 2023Review
- Characterization and in-vitro Alzheimer's properties of exopolysaccharide from Bacillus maritimus MSM1.Scientific reports · 2023Article
- Molecular Characterization ofInternational journal of molecular sciences · 2023Article
- The role of tyrosine hydroxylase as a key player in neuromelanin synthesis and the association of neuromelanin with Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidized metabolites of dopamine known as dopamine quinone derivatives are thought to play a pivotal role in the degeneration of nigrostriatal dopaminergic neurons in Parkinson's disease. Although such quinone derivatives are usually produced via the autoxidation of catecholamines, tyrosinase, which is a key enzyme in melanin biosynthesis via the production of DOPA and subsequent molecules, can potentially accelerate the induction of catecholamine quinone derivatives by its oxidase activity. We have developed neuronal cell lines in which the expression of human tyrosinase was inducible. Overexpression of tyrosinase resulted in increased intracellular dopamine content in association with the formation of melanin pigments in neuronal somata, which eventually causes apoptotic cell death. This cellular model will provide a useful tool for detailed analyses of the neurotoxicity of oxidized catechol metabolites.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.