ReviewMarine drugs2010
Microtubule-stabilizing drugs from marine sponges: focus on peloruside A and zampanolide.
Review in Marine drugs, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Article
- LC-MS based metabolic fingerprinting of apricot pistils after self-compatible and self-incompatible pollinations.Plant molecular biology · 2021Article
- Quest for Efficacious Next-Generation Taxoid Anticancer Agents and Their Tumor-Targeted Delivery.Journal of natural products · 2018Review
- First Report on Chitin in a Non-Verongiid Marine Demosponge: The Mycale euplectellioides Case.Marine drugs · 2018Article
- Marine Sponge Natural Products with Anticancer Potential: An Updated Review.Marine drugs · 2017Review
- Pharmacokinetic Analysis and in Vivo Antitumor Efficacy of Taccalonolides AF and AJ.Journal of natural products · 2017Article
- Antiproliferative and Proapoptotic Activities of Marine SpongePharmacognosy magazine · 2017Article
- Axonal Transport and Neurodegeneration: How Marine Drugs Can Be Used for the Development of Therapeutics.Marine drugs · 2016Review
- Drug discovery targeting cell division proteins, microtubules and FtsZ.Bioorganic & medicinal chemistry · 2014Review
- Zampanolide and dactylolide: cytotoxic tubulin-assembly agents and promising anticancer leads.Natural product reports · 2014Review
- Metabolomic tools for secondary metabolite discovery from marine microbial symbionts.Marine drugs · 2014Article
- Synthesis and SAR of Lehualide B: a marine-derived natural product with potent anti-multiple myeloma activity.ACS chemical biology · 2013Article
- Peloruside, laulimalide, and noscapine interactions with beta-tubulin.Pharmaceutical research · 2012Review
- Mycalamide A shows cytotoxic properties and prevents EGF-induced neoplastic transformation through inhibition of nuclear factors.Marine drugs · 2012Article
- Bioactive substances with anti-neoplastic efficacy from marine invertebrates: Porifera and Coelenterata.World journal of clinical oncology · 2011Article
- Ethyl acetate extract from marine sponge Hyattella cribriformis exhibit potent anticancer activity by promoting tubulin polymerization as evidenced mitotic arrest and induction of apoptosis.Pharmacognosy magazineArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Marine sponges are an excellent source of bioactive secondary metabolites with potential therapeutic value in the treatment of diseases. One group of compounds of particular interest is the microtubule-stabilizing agents, the most well-known compound of this group being paclitaxel (Taxol), an anti-cancer compound isolated from the bark and leaves of the Pacific yew tree. This review focuses on two of the more recent additions to this important class of drugs, peloruside A and zampanolide, both isolated from marine sponges. Peloruside A was isolated from Mycale hentscheli collected in New Zealand coastal waters, and it already shows promising anti-cancer activity. Two other potent bioactive compounds with different modes of action but isolated from the same sponge, mycalamide A and pateamine, will also be discussed. The fourth compound, zampanolide, most recently isolated from the Tongan sponge Cacospongia mycofijiensis, has only recently been added to the microtubule-stabilizing group of compounds, and further work is in progress to determine its activity profile relative to peloruside A and other drugs of this class.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.