ArticleMolecular psychiatry2011
Maternal warmth buffers the effects of low early-life socioeconomic status on pro-inflammatory signaling in adulthood.
Article in Molecular psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02123160 (Dyadic Therapy for Mothers and Children), which is not on this map. Cited by 173 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dyadic Therapy for Mothers and Children
Who cites it
173 citing papers in PubMed, 5 syntheses or guidelines pooled it, 337 citations in OpenAlex.
- The Link Between Positive and Negative Parenting Behaviors and Child Inflammation: A Systematic Review.Child psychiatry and human development · 2023Pooled it
- Sickness and the Social Brain: Love in the Time of COVID.Frontiers in psychiatry · 2021Pooled it
- Aberrant Epigenomic Modulation of Glucocorticoid Receptor Gene (NR3C1) in Early Life Stress and Major Depressive Disorder Correlation: Systematic Review and Quantitative Evidence Synthesis.International journal of environmental research and public health · 2019Pooled it
- [Inflammatory Biomarkers and Postpartum Depression: A Systematic Review of Literature].Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2019Pooled it
- Blood transcriptomic comparison of individuals with and without autism spectrum disorder: A combined-samples mega-analysis.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Pooled it
- Attachment insecurity moderates emotion responses to mindfulness and loving-kindness meditation in adults raised in low socioeconomic status households.Emotion (Washington, D.C.) · 2022Trial
- Unsupportive parenting moderates the effects of family psychosocial intervention on metabolic syndrome in African American youth.International journal of obesity (2005) · 2018Trial
- Protective Prevention Effects on the Association of Poverty With Brain Development.JAMA pediatrics · 2017Trial
- Biological marks of early-life socioeconomic experience is detected in the adult inflammatory transcriptome.Scientific reports · 2016Trial
- Stress management, leukocyte transcriptional changes and breast cancer recurrence in a randomized trial: An exploratory analysis.Psychoneuroendocrinology · 2016Trial
- Trait sensitivity to social disconnection enhances pro-inflammatory responses to a randomized controlled trial of endotoxin.Psychoneuroendocrinology · 2015Trial
- A family-oriented psychosocial intervention reduces inflammation in low-SES African American youth.Proceedings of the National Academy of Sciences of the United States of America · 2014Trial
- Childhood abuse, parental warmth, and adult multisystem biological risk in the Coronary Artery Risk Development in Young Adults study.Proceedings of the National Academy of Sciences of the United States of America · 2013Trial
- Yogic meditation reverses NF-κB and IRF-related transcriptome dynamics in leukocytes of family dementia caregivers in a randomized controlled trial.Psychoneuroendocrinology · 2013Trial
- Cognitive-behavioral stress management reverses anxiety-related leukocyte transcriptional dynamics.Biological psychiatry · 2012Trial
- Dietary Inflammatory Index and Depressive Symptoms in Chinese University Students Leveraging an Intelligent Ordering System: 3-Year Longitudinal Prospective Cohort Study.Journal of medical Internet research · 2026Article
- Longitudinal associations between father- and mother-child interactions, coparenting, and child cardiometabolic health.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Article
- Relationship between poverty and symptoms of depression and anxiety among adolescents in Nepal: Examining the mediating effect of external and internal resilience.Journal of affective disorders · 2026Article
- From Womb to Mind: Prenatal Epigenetic Influences on Mental Health Disorders.International journal of molecular sciences · 2025Review
- Birthing parents' neural response to infant cry: moderating effects of oxytocin and perceived childhood care.Social cognitive and affective neuroscience · 2025Article
113 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The notion that family support may buffer individuals under adversity from poor outcomes has been theorized to have important implications for mental and physical health, but little is known about the biological mechanisms that explain these links. We hypothesized that adults who grew up in low socioeconomic status (SES) households but who experienced high levels of maternal warmth would be protected from the pro-inflammatory states typically associated with low SES. A total of 53 healthy adults (aged 25-40 years) low in SES early in life were assessed on markers of immune activation and systemic inflammation. Genome-wide transcriptional profiling also was conducted. Low early-life SES individuals who had mothers, who expressed high warmth toward them, exhibited less Toll-like receptor-stimulated production of interleukin 6, and reduced bioinformatic indications of pro-inflammatory transcription factor activity (NF-κB) and immune activating transcription factor activity (AP-1) compared to those who were low in SES early in life but experienced low maternal warmth. To the extent that such effects are causal, they suggest the possibility that the detrimental immunologic effects of low early-life SES environments may be partly diminished through supportive family climates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.