ArticleJournal of neurosurgical anesthesiology2010
Age-related defects in sensorimotor activity, spatial learning, and memory in C57BL/6 mice.
Article in Journal of neurosurgical anesthesiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
51 citing papers in PubMed, 81 citations in OpenAlex.
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- Longitudinal characterization reveals behavioral impairments in aged APP knock in mouse models.Scientific reports · 2025Article
- Prophylactic senolytic treatment in aged mice reduces seizure severity and improves survival from Status Epilepticus.Aging cell · 2024Article
- Small extracellular vesicles from young plasma reverse age-related functional declines by improving mitochondrial energy metabolism.Nature aging · 2024Article
- Effects of a ketogenic diet on motor function and motor unit number estimation in aged C57BL/6 mice.The journal of nutrition, health & aging · 2024Article
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- Age-related differences in affective behaviors in mice: possible role of prefrontal cortical-hippocampal functional connectivity and metabolomic profiles.Frontiers in aging neuroscience · 2024Article
- In vivo adenine base editing corrects newborn murine model of Hurler syndrome.Molecular biomedicine · 2023Article
- A novel transgenic mouse model expressing primate-specific nuclear choline acetyltransferase: insights into potential cholinergic vulnerability.Scientific reports · 2023Article
- Sex- and age-dependent contribution of System xFrontiers in behavioral neuroscience · 2023Article
- RNA-sequencing Reveals a Gene Expression Signature in Skeletal Muscle of a Mouse Model of Age-associated Postoperative Functional Decline.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
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- Physiological Systems in Promoting Frailty.Comprehensive Physiology · 2022Review
- Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing.Molecular psychiatry · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Impaired locomotor activity and spatial memory are common features in the natural aging process, and aging is an important risk factor for neurodegenerative disease and postoperative cognitive dysfunction. To characterize age-related changes in psychomotor performance, we assessed sensorimotor activity, spatial learning, and memory in C57BL/6 mice using the Rotarod, foot fault, and Barnes Maze tests. Old mice exhibit significant deficits in locomotor activity and spatial memory relative to young mice, but improve with training. These tests will be useful to assess outcome in neurodegenerative disease and postoperative cognitive dysfunction models carried out in aged mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.