ArticleGenetics2010
Evolution of a distinct genomic domain in Drosophila: comparative analysis of the dot chromosome in Drosophila melanogaster and Drosophila virilis.
Article in Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed.
- Accessible support at a national scale: the use and value of virtual learning assistants across multiple undergraduate institutions.Journal of microbiology & biology education · 2025Article
- The Genomics Education Partnership: First findings on genomics research in community colleges.Scholarship and practice of undergraduate research · 2023Article
- Manual annotation ofF1000Research · 2022Article
- TheGenetics · 2018Article
- The Need to Be Sure About CUREs: Discovery and Relevance as Critical Elements of CUREs for Nonmajors.Journal of microbiology & biology education · 2018Article
- Retrotransposons Are the Major Contributors to the Expansion of theG3 (Bethesda, Md.) · 2017Article
- The house fly Y Chromosome is young and minimally differentiated from its ancient X Chromosome partner.Genome research · 2017Article
- Genomic changes following the reversal of a Y chromosome to an autosome in Drosophila pseudoobscura.Evolution; international journal of organic evolution · 2017Article
- Article
- Comparative Genomic Analyses Provide New Insights into the Evolutionary Dynamics of Heterochromatin in Drosophila.PLoS genetics · 2016Article
- Early Engagement in Course-Based Research Increases Graduation Rates and Completion of Science, Engineering, and Mathematics Degrees.CBE life sciences education · 2016Article
- Ancestral Chromatin Configuration Constrains Chromatin Evolution on Differentiating Sex Chromosomes in Drosophila.PLoS genetics · 2015Article
- Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution.G3 (Bethesda, Md.) · 2015Article
- Tetris is a foldback transposon that provided the building blocks for an emerging satellite DNA of Drosophila virilis.Genome biology and evolution · 2014Article
- A central support system can facilitate implementation and sustainability of a Classroom-based Undergraduate Research Experience (CURE) in Genomics.CBE life sciences education · 2014Article
- A course-based research experience: how benefits change with increased investment in instructional time.CBE life sciences education · 2014Article
- Assessment of course-based undergraduate research experiences: a meeting report.CBE life sciences education · 2014Article
- Enrichment of HP1a on Drosophila chromosome 4 genes creates an alternate chromatin structure critical for regulation in this heterochromatic domain.PLoS genetics · 2012Article
- Buffering and the evolution of chromosome-wide gene regulation.Chromosoma · 2011Review
- The 19 genomes of Drosophila: a BAC library resource for genus-wide and genome-scale comparative evolutionary research.Genetics · 2011Article
Corrections and comments
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Authors and funding
31 authors.
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Abstract
The distal arm of the fourth ("dot") chromosome of Drosophila melanogaster is unusual in that it exhibits an amalgamation of heterochromatic properties (e.g., dense packaging, late replication) and euchromatic properties (e.g., gene density similar to euchromatic domains, replication during polytenization). To examine the evolution of this unusual domain, we undertook a comparative study by generating high-quality sequence data and manually curating gene models for the dot chromosome of D. virilis (Tucson strain 15010-1051.88). Our analysis shows that the dot chromosomes of D. melanogaster and D. virilis have higher repeat density, larger gene size, lower codon bias, and a higher rate of gene rearrangement compared to a reference euchromatic domain. Analysis of eight "wanderer" genes (present in a euchromatic chromosome arm in one species and on the dot chromosome in the other) shows that their characteristics are similar to other genes in the same domain, which suggests that these characteristics are features of the domain and are not required for these genes to function. Comparison of this strain of D. virilis with the strain sequenced by the Drosophila 12 Genomes Consortium (Tucson strain 15010-1051.87) indicates that most genes on the dot are under weak purifying selection. Collectively, despite the heterochromatin-like properties of this domain, genes on the dot evolve to maintain function while being responsive to changes in their local environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.