ArticleGenetics2010
Extensive loss of RNA editing sites in rapidly evolving Silene mitochondrial genomes: selection vs. retroprocessing as the driving force.
Article in Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed.
- Assembly and comparative analysis of the complete mitochondrial genome of the endangered plant Fraxinus mandshurica.BMC plant biology · 2026Article
- Assembly and comparative analysis of the complete mitochondrial genome of Viola philippica (Malpighiales, Violaceae).Planta · 2026Article
- The first complete assembly and analysis of mitochondrial genome of Pinus thunbergii in Pinaceae.BMC plant biology · 2026Article
- Recombination and Retroprocessing in Broomrapes Reveal RNA-Mediated Gene Transfer Mechanism and a Generalizable Model for Mitochondrial Evolution in Heterotrophic Plants.Genome biology and evolution · 2026Article
- Mitogenome assembly and phylogenetic relationships ofFrontiers in plant science · 2026Article
- Assembly and comparative analysis of the multipartite mitochondrial genome ofFrontiers in plant science · 2026Article
- Can transcriptome size and off-target effects explain the contrasting evolution of mitochondrial vs nuclear RNA editing?Journal of evolutionary biology · 2025Article
- High Conservation of Translation-Enabling RNA Editing Sites in Hyper-editing Ferns Implies They Are Not Selectively Neutral.Molecular biology and evolution · 2025Article
- Complete mitochondrial genome of Polygonatum cyrtonema Hua reveals variation diversity and evolutionary trends.BMC plant biology · 2025Article
- Complete mitochondrial genome assembly and comparative analysis of Fagopyrum dibotrys (Golden Buckwheat).BMC plant biology · 2025Article
- Assembly and comparative analysis of the complete mitochondrial genome of the spice plant Cinnamomum longepaniculatum.BMC plant biology · 2025Article
- Complete analysis and phylogenetic analysis of Polygonatum sibiricum mitochondria.BMC plant biology · 2025Article
- Complete mitochondrial genome of Agropyron cristatum reveals gene transfer and RNA editing events.BMC plant biology · 2024Article
- From barcodes to genomes: a new era of molecular exploration in bryophyte research.Frontiers in plant science · 2024Review
- Comparative analysis of the mitochondrial genomes of fourFrontiers in plant science · 2024Article
- Assembly and analysis of the complete mitochondrial genome of Forsythia suspensa (Thunb.) Vahl.BMC genomics · 2023Article
- Article
- Characterisation of the complete mitochondrial genome of Taraxacum mongolicum revealed five repeat-mediated recombinations.Plant cell reports · 2023Article
- Emergence of Novel RNA-Editing Sites by Changes in the Binding Affinity of a Conserved PPR Protein.Molecular biology and evolution · 2022Article
- A Comprehensive Evolutionary Study of Chloroplast RNA Editing in Gymnosperms: A Novel Type of G-to-A RNA Editing Is Common in Gymnosperms.International journal of molecular sciences · 2022Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
Abstract
Theoretical arguments suggest that mutation rates influence the proliferation and maintenance of RNA editing. We identified RNA editing sites in five species within the angiosperm genus Silene that exhibit highly divergent mitochondrial mutation rates. We found that mutational acceleration has been associated with rapid loss of mitochondrial editing sites. In contrast, we did not find a significant difference in the frequency of editing in chloroplast genes, which lack the mutation rate variation observed in the mitochondrial genome. As found in other angiosperms, the rate of substitution at RNA editing sites in Silene greatly exceeds the rate at synonymous sites, a pattern that has previously been interpreted as evidence for selection against RNA editing. Alternatively, we suggest that editing sites may experience higher rates of C-to-T mutation than other portions of the genome. Such a pattern could be caused by gene conversion with reverse-transcribed mRNA (i.e., retroprocessing). If so, the genomic distribution of RNA editing site losses in Silene suggests that such conversions must be occurring at a local scale such that only one or two editing sites are affected at a time. Because preferential substitution at editing sites appears to occur in angiosperms regardless of the mutation rate, we conclude that mitochondrial rate accelerations within Silene have "fast-forwarded" a preexisting pattern but have not fundamentally changed the evolutionary forces acting on RNA editing sites.
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