ArticleGenes & development2010
Memories of lost enhancers.
Article in Genes & development, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Oncogenic lncRNA transgene transcription modulates epigenetic memory at a naïve chromosomal locus.Nucleus (Austin, Tex.) · 2025Article
- Transcriptional enhancers and their communication with gene promoters.Cellular and molecular life sciences : CMLS · 2021Review
- Cohesin-Dependent and -Independent Mechanisms Mediate Chromosomal Contacts between Promoters and Enhancers.Cell reports · 2020Article
- Charting the cis-regulome of activated B cells by coupling structural and functional genomics.Nature immunology · 2020Article
- Enhancer Runaway and the Evolution of Diploid Gene Expression.PLoS genetics · 2015Article
- Genome-wide and single-cell analyses reveal a context dependent relationship between CBP recruitment and gene expression.Nucleic acids research · 2014Article
- Uncovering enhancer functions using the α-globin locus.PLoS genetics · 2014Review
- Loss of an Igκ gene enhancer in mature B cells results in rapid gene silencing and partial reversible dedifferentiation.Molecular and cellular biology · 2013Article
- Inducible mouse models illuminate parameters influencing epigenetic inheritance.Development (Cambridge, England) · 2013Article
- Regulatory consequences of gene translocation in bacteria.Nucleic acids research · 2012Article
- CD4-CD8 differentiation in the thymus: connecting circuits and building memories.Current opinion in immunology · 2012Review
- Human tRNA genes function as chromatin insulators.The EMBO journal · 2012Article
- Enhancer-promoter communication and transcriptional regulation of Igh.Trends in immunology · 2011Review
- The eleven-nineteen lysine-rich leukemia gene (ELL2) influences the histone H3 protein modifications accompanying the shift to secretory immunoglobulin heavy chain mRNA production.The Journal of biological chemistry · 2011Article
- The Igκ gene enhancers, E3' and Ed, are essential for triggering transcription.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Molecular analysis of enhancer RNAs and chromatin modifications in the region of their synthesis in Drosophila cells possessing genetic constructs.Doklady. Biochemistry and biophysicsArticle
- Molecular analysis of RNA induced by enhancer in Drosophila cells carrying reporter genetic constructs.Doklady. Biochemistry and biophysicsArticle
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Abstract
Transcriptional enhancers are key determinants of developmentally regulated gene expression. Models of enhancer function must distinguish between analog or digital control of transcription, as well as their requirement to initiate or maintain transcriptional activity of a gene. In light of a recent study by Chong and colleagues (pp. 659-669) providing evidence of a transient requirement of an enhancer associated with the CD4 gene, we discuss possible mechanisms by which transcriptional memory can be propagated in the absence of enhancers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.