ArticleThe Journal of physiology2010
Properties of low-threshold motor axons in the human median nerve.
Article in The Journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 54 citations in OpenAlex.
- The voltage dependence of I(h) in human myelinated axons.The Journal of physiology · 2012Trial
- Dose effects of oxaliplatin on persistent and transient Na+ conductances and the development of neurotoxicity.PloS one · 2011Trial
- A nociceptor excitability test for identifying alterations of the Nav1.7 channels in humans.Pain · 2026Article
- Characteristics of posterior root reflexes evoked by transcutaneous spinal stimulation with various pulse durations.Journal of neurophysiology · 2026Article
- Influence of transcutaneous electrical nerve stimulation on walking kinematics and standing balance of older adults who differ in walking speed.Experimental brain research · 2023Article
- The effect of the subthreshold oscillation induced by the neurons' resonance upon the electrical stimulation-dependent instability.Frontiers in neuroscience · 2023Article
- The test-retest reliability of large and small fiber nerve excitability testing with threshold tracking.Clinical neurophysiology practice · 2023Article
- Human adipose-derived mesenchymal stem cell-conditioned medium ameliorates polyneuropathy and foot ulceration in diabetic BKS db/db mice.Stem cell research & therapy · 2020Article
- From Perception Threshold to Ion Channels-A Computational Study.Biophysical journal · 2019Article
- Upper and lower limb motor axons demonstrate differential excitability and accommodation to strong hyperpolarizing currents during induced hyperthermia.Journal of neurophysiology · 2019Article
- In vivo evidence for reduced ion channel expression in motor axons of patients with amyotrophic lateral sclerosis.The Journal of physiology · 2018Article
- Characterization of diabetic neuropathy progression in a mouse model of type 2 diabetes mellitus.Biology open · 2018Article
- Hyperpolarization-activated cyclic-nucleotide-gated channels potentially modulate axonal excitability at different thresholds.Journal of neurophysiology · 2017Article
- Excitability and firing behavior of single slow motor axons transmitting natural repetitive firing of human motoneurons.Journal of neurophysiology · 2017Article
- F-wave of single firing motor units: correct or misleading criterion of motoneuron excitability in humans?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017Article
- TheFrontiers in molecular neuroscience · 2017Article
- Reduced mirror neuron activity in schizophrenia and its association with theory of mind deficits: evidence from a transcranial magnetic stimulation study.Schizophrenia bulletin · 2014Article
- IH activity is increased in populations of slow versus fast motor axons of the rat.Frontiers in human neuroscience · 2014Article
- Inward rectifying channels as new targets for treatment.The Journal of physiology · 2010Article
- Mirror neuron dysfunction and ego-boundary disturbances in schizophrenia: a transcranial magnetic stimulation study.Indian journal of psychological medicineArticle
Corrections and comments
- Commented on by
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated the excitability and accommodative properties of low-threshold human motor axons to test whether these motor axons have greater expression of the persistent Na(+) conductance, I(NaP). Computer-controlled threshold tracking was used to study 22 single motor units and the data were compared with compound motor potentials of various amplitudes recorded in the same experimental session. Detailed comparisons were made between the single units and compound potentials that were 40% or 5% of maximal amplitude, the former because this is the compound potential size used in most threshold tracking studies of axonal excitability, the latter because this is the compound potential most likely to be composed entirely of motor axons with low thresholds to electrical recruitment. Measurements were made of the strength-duration relationship, threshold electrotonus, current-voltage relationship, recovery cycle and latent addition. The findings did not support a difference in I(NaP). Instead they pointed to greater activity of the hyperpolarization-activated inwardly rectifying current (I(h)) as the basis for low threshold to electrical recruitment in human motor axons. Computer modelling confirmed this finding, with a doubling of the hyperpolarization-activated conductance proving the best single parameter adjustment to fit the experimental data. We suggest that the hyperpolarization-activated cyclic nucleotide-gated (HCN) channel(s) expressed on human motor axons may be active at rest and contribute to resting membrane potential.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.