ArticleBMJ (Clinical research ed.)2010
Glycated haemoglobin A1c for diagnosing diabetes in Chinese population: cross sectional epidemiological survey.
Article in BMJ (Clinical research ed.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
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Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 134 citations in OpenAlex.
- Characteristics of participants who take up screening tests for diabetes and lipid disorders: a systematic review.BMJ open · 2022Pooled it
- Diastolic dysfunction predicts the risk of contrast-induced nephropathy and outcome post-emergency percutaneous coronary intervention in AMI patients with preserved ejection fraction.Heart and vessels · 2018Trial
- Can HbA1c replace OGTT for the diagnosis of diabetes mellitus among Chinese patients with impaired fasting glucose?Family practice · 2015Trial
- Nateglinide and acarbose are comparably effective reducers of postprandial glycemic excursions in chinese antihyperglycemic agent-naive subjects with type 2 diabetes.Diabetes technology & therapeutics · 2013Trial
- Evaluation for fasting and 2-hour glucose and HbA1c for diagnosing diabetes based on prevalence of retinopathy in a Chinese population.PloS one · 2012Trial
- Quantitative metabolomics and machine learning identify differential metabolomic biomarkers across normoglycaemia, pre-diabetes and diabetes in a Qinghai Plateau population.BMJ public health · 2026Article
- Evaluation of the diagnostic efficacy of different glycemic markers and insulin indices for diabetes mellitus in a general population.Annals of medicine · 2025Article
- The Effect of Yoga and Gastro-Hepatic Pack on Type 2 Diabetes Mellitus: A Four-Arm Randomized Controlled Study.Cureus · 2025Article
- Optimal Glycated Hemoglobin Cutoff for Diagnosis of Diabetes and Prediabetes in Chinese Breast Cancer Women.International journal of general medicine · 2024Article
- Article
- Evaluating the predictive value of diabetes mellitus diagnosed according to the Chinese guidelines (2020 edition) for cardiovascular events.Diabetology & metabolic syndrome · 2022Article
- [Effectiveness of different screening strategies for type 2 diabete on preventing cardiovascular diseases in a community-based Chinese population using a decision-analytic Markov model].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2022Article
- The relationship between sex hormones and glycated hemoglobin in a non-diabetic middle-aged and elderly population.BMC endocrine disorders · 2022Article
- Revised Glycemic Index for Diagnosing and Monitoring of Diabetes Mellitus in South Indian Population.Cureus · 2022Article
- Portable and Intelligent Urine Glucose Analyzer Based on a CdTe QDs@GOx Aerogel Circular Array Sensor.ACS omega · 2021Article
- A formula based on autonomic test using EZSCAN and anthropometric data for diagnosis of DM in China.Scientific reports · 2020Article
- Prevalence of Diabetes and Prediabetes in Adults from a Third-Tier City in Eastern China: A Cross-Sectional Study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2019Article
- Identification of Newly Diagnosed Diabetes and Prediabetes Using Fasting Plasma Glucose and Urinary Glucose in a Chinese Population: A Multicenter Cross-Sectional Study.Chinese medical journal · 2018Article
- Verification of a novel point-of-care HbABiochemia medica · 2018Article
- Analysis of Changes in Retinal Thickness in Type 2 Diabetes without Diabetic Retinopathy.Journal of diabetes research · 2018Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate haemoglobin A1c (HbA(1c)) in diagnosing diabetes and identify the optimal HbA(1c) threshold to be used in Chinese adults.
designMultistage stratified cross sectional epidemiological survey.
settingShanghai, China, 2007-8.
participants4886 Chinese adults over 20 years of age with no history of diabetes.
main outcome measuresPerformance of HbA(1c) at increasing thresholds for diagnosing diabetes.
resultsThe area under the receiver operating characteristics curve for detecting undiagnosed diabetes was 0.856 (95% confidence interval 0.828 to 0.883) for HbA(1c) alone and 0.920 (0.900 to 0.941) for fasting plasma glucose alone. Very high specificity (96.1%, 95% confidence interval 95.5% to 96.7%) was achieved at an HbA(1c) threshold of 6.3% (2 SD above the normal mean). Moreover, the corresponding sensitivity was 62.8% (57.1% to 68.3%), which was equivalent to that of a fasting plasma glucose threshold of 7.0 mmol/l (57.5%, 51.7% to 63.1%) in detecting undiagnosed diabetes. In participants at high risk of diabetes, the HbA(1c) threshold of 6.3% showed significantly higher sensitivity (66.9%, 61.0% to 72.5%) than both fasting plasma glucose >or=7.0 mmol/l (54.4%, 48.3% to 60.4%) and HbA(1c) >or=6.5% (53.7%, 47.6% to 59.7%) (P<0.01).
conclusionsAn HbA(1c) threshold of 6.3% was highly specific for detecting undiagnosed diabetes in Chinese adults and had sensitivity similar to that of using a fasting plasma glucose threshold of 7.0 mmol/l. This optimal HbA(1c) threshold may be suitable as a diagnostic criterion for diabetes in Chinese adults when fasting plasma glucose and oral glucose tolerance tests are not available.
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