ReviewPediatrics2010
Mechanisms and regulation of the gene-expression response to sepsis.
Review in Pediatrics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- LBP rs2232618 polymorphism contributes to risk of sepsis after trauma.World journal of emergency surgery : WJES · 2018Pooled it
- Role of interleukins in the detection of neonatal sepsis: a network meta-analysis.Frontiers in pediatrics · 2023Article
- Biomarkers for the Prediction and Judgement of Sepsis and Sepsis Complications: A Step towardsJournal of clinical medicine · 2022Review
- Endothelial Damage in Sepsis: The Importance of Systems Biology.Frontiers in pediatrics · 2022Review
- Diagnosis of neonatal sepsis: the past, present and future.Pediatric research · 2022Review
- Role of Zinc in Neonatal Sepsis.Indian journal of pediatrics · 2021Review
- The Diagnostic Value of FeTherapeutics and clinical risk management · 2021Article
- Gene Expression Profiles in Children With Suspected Sepsis.Annals of emergency medicine · 2020Review
- Impact of cytomegalovirus load on host response to sepsis.Medical microbiology and immunology · 2019Review
- Cytokine storm and sepsis disease pathogenesis.Seminars in immunopathology · 2017Review
- Bugs, genes, and the intensive care unit.Journal of thoracic disease · 2016Article
- Sepsis in preterm infants causes alterations in mucosal gene expression and microbiota profiles compared to non-septic twins.Scientific reports · 2016Article
- Neonatal infections in Saudi Arabia: Association with cytokine gene polymorphisms.Central-European journal of immunology · 2015Article
- Biology of sepsis: its relevance to pediatric nephrology.Pediatric nephrology (Berlin, Germany) · 2014Review
- Elevated postinjury thrombospondin 1-CD47 triggering aids differentiation of patients' defective inflammatory CD1a+dendritic cells.Journal of leukocyte biology · 2014Article
- Epidemiology of bronchopulmonary dysplasia.Birth defects research. Part A, Clinical and molecular teratology · 2014Review
- Sepsis biomarkers: an omics perspective.Frontiers of medicine · 2014Review
- Multiple gene-to-gene interactions in children with sepsis: a combination of five gene variants predicts outcome of life-threatening sepsis.Critical care (London, England) · 2014Article
- DNA methylation pattern of CALCA in preterm neonates with bacterial sepsis as a putative epigenetic biomarker.Epigenetics · 2013Article
- Bench-to-bedside review: future novel diagnostics for sepsis - a systems biology approach.Critical care (London, England) · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Sepsis is defined as the systemic inflammatory response of the human host that is triggered by an invading pathogen. Despite tremendous advances in both our knowledge of and treatment strategies for this syndrome, sepsis remains among the major causes of morbidity and mortality in children worldwide. Thus, we hypothesize that an improved mechanistic understanding obtained via basic and translational science will continue to identify novel therapeutic targets and approaches. As a result, given the central importance of the alterations in gene expression in regulating the human host's physiologic response to a pathogen, we review the complex factors-genetics, transcriptional expression, and epigenetics-that regulate unique gene-expression patterns in pediatric sepsis and septic shock. We anticipate that emerging data from genetic, genomic, and other translation studies in pediatric sepsis will advance our biological understanding of this response and undoubtedly identify targets for newer therapies.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.