ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2010
Mutational fitness effects in RNA and single-stranded DNA viruses: common patterns revealed by site-directed mutagenesis studies.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
99 citing papers in PubMed, 209 citations in OpenAlex.
- Quantifying the diversification of hepatitis C virus (HCV) during primary infection: estimates of the in vivo mutation rate.PLoS pathogens · 2012Trial
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- Phylogenetic and Proteomic Analyses of Segment 2 Sequence Reveals the Presence of Two Variants of a Divergent Amnoonvirus (Family:Microorganisms · 2026Article
- Phylodynamics beyond neutrality: the impact of incomplete purifying selection on viral phylogenies and inference.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Lethal mutagenesis and the transient within-host dynamics of viral adaptation.Virus evolution · 2025Article
- A review of the venom microbiome and its utility in ecology and evolution including future directions for emerging research.Symbiosis (Philadelphia, Pa.) · 2025Article
- Evolutionary rescue effect can disappear under non-neutral mutations-a reply to Zhang et al. (2022).Nature communications · 2024Article
- Quantifying the strength of viral fitness trade-offs between hosts: a meta-analysis of pleiotropic fitness effects.Evolution letters · 2024Article
- Quasispecies theory and emerging viruses: challenges and applications.Npj viruses · 2024Review
- Spillover: Mechanisms, Genetic Barriers, and the Role of Reservoirs in Emerging Pathogens.Microorganisms · 2024Review
- Genetic and phenotypic changes to Venezuelan equine encephalitis virus following treatment with β-D-N4-hydroxycytidine, an RNA mutagen.Scientific reports · 2024Article
- Modeling viral evolution: A novel SIRSVIDE framework with application to SARS-CoV-2 dynamics.hLife · 2024Article
- Changing fitness effects of mutations through long-term bacterial evolution.Science (New York, N.Y.) · 2024Article
- Viral Evolution Shaped by Host Proteostasis Networks.Annual review of virology · 2023Review
- Genome-wide study of globally distributed respiratory syncytial virus (RSV) strains implicates diversification utilizing phylodynamics and mutational analysis.Scientific reports · 2023Article
- Evolutionary safety of lethal mutagenesis driven by antiviral treatment.PLoS biology · 2023Article
- A null model for the distribution of fitness effects of mutations.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Developing an appropriate evolutionary baseline model for the study of SARS-CoV-2 patient samples.PLoS pathogens · 2023Review
- Article
- Mutation rate, selection, and epistasis inferred from RNA virus haplotypes via neural posterior estimation.Virus evolution · 2023Article
39 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The fitness effects of mutations are central to evolution, yet have begun to be characterized in detail only recently. Site-directed mutagenesis is a powerful tool for achieving this goal, which is particularly suited for viruses because of their small genomes. Here, I discuss the evolutionary relevance of mutational fitness effects and critically review previous site-directed mutagenesis studies. The effects of single-nucleotide substitutions are standardized and compared for five RNA or single-stranded DNA viruses infecting bacteria, plants or animals. All viruses examined show very low tolerance to mutation when compared with cellular organisms. Moreover, for non-lethal mutations, the mean fitness reduction caused by single mutations is remarkably constant (0.10-0.13), whereas the fraction of lethals varies only modestly (0.20-0.41). Other summary statistics are provided. These generalizations about the distribution of mutational fitness effects can help us to better understand the evolution of RNA and single-stranded DNA viruses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.