ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2010
Pathways to extinction: beyond the error threshold.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Bifurcations and phase transitions in the origins of life.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Emergence of ATP- and GTP-Binding Aptamers from Single RNA Sequences by Error-Prone Replication and Selection.ChemSystemsChem · 2023Article
- Genetic diversity through social heterosis can increase virulence in RNA viral infections and cancer progression.Royal Society open science · 2021Article
- Structural Insights Into Tautomeric Dynamics in Nucleic Acids and in Antiviral Nucleoside Analogs.Frontiers in molecular biosciences · 2021Review
- Small-Molecule Antiviral β-d-Journal of virology · 2019Article
- Endemicity and prevalence of multipartite viruses under heterogeneous between-host transmission.PLoS computational biology · 2019Article
- The Curious Case of the Nidovirus Exoribonuclease: Its Role in RNA Synthesis and Replication Fidelity.Frontiers in microbiology · 2019Review
- Low-fidelity Venezuelan equine encephalitis virus polymerase mutants to improve live-attenuated vaccine safety and efficacy.Virus evolution · 2018Article
- Mosquito bottlenecks alter viral mutant swarm in a tissue and time-dependent manner with contraction and expansion of variant positions and diversity.Virus evolution · 2018Article
- Collective Infectious Units in Viruses.Trends in microbiology · 2017Review
- Two sides of the same coin: A population genetics perspective on lethal mutagenesis and mutational meltdown.Virus evolution · 2017Article
- Multipartite viruses: adaptive trick or evolutionary treat?NPJ systems biology and applications · 2017Review
- Arenavirus Quasispecies and Their Biological Implications.Current topics in microbiology and immunology · 2016Review
- Single-Cell Analysis of RNA Virus Infection Identifies Multiple Genetically Diverse Viral Genomes within Single Infectious Units.Cell host & microbe · 2015Article
- Tautomerism provides a molecular explanation for the mutagenic properties of the anti-HIV nucleoside 5-aza-5,6-dihydro-2'-deoxycytidine.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations.Scientific reports · 2014Article
- Intergenerational phenotypic mixing in viral evolution.Evolution; international journal of organic evolution · 2013Article
- Back to the future: revisiting HIV-1 lethal mutagenesis.Trends in microbiology · 2013Article
- Article
- Implications of altered replication fidelity on the evolution and pathogenesis of coronaviruses.Current opinion in virology · 2012Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since the introduction of the quasispecies and the error catastrophe concepts for molecular evolution by Eigen and their subsequent application to viral populations, increased mutagenesis has become a common strategy to cause the extinction of viral infectivity. Nevertheless, the high complexity of virus populations has shown that viral extinction can occur through several other pathways apart from crossing an error threshold. Increases in the mutation rate enhance the appearance of defective forms and promote the selection of mechanisms that are able to counteract the accelerated appearance of mutations. Current models of viral evolution take into account more realistic scenarios that consider compensatory and lethal mutations, a highly redundant genotype-to-phenotype map, rough fitness landscapes relating phenotype and fitness, and where phenotype is described as a set of interdependent traits. Further, viral populations cannot be understood without specifying the characteristics of the environment where they evolve and adapt. Altogether, it turns out that the pathways through which viral quasispecies go extinct are multiple and diverse.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.