Trial reportThe American journal of psychiatry2010
Treatment of Resistant Depression in Adolescents (TORDIA): week 24 outcomes.
Trial report in The American journal of psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 77 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Treatment of SSRI-Resistant Depression in Adolescents (TORDIA)
A Preliminary Study of the Efficacy and Safety of Carbamazepine in Severe Liver Disease Due to Alpha-1 Antitrypsin Deficiency
Sequenced Treatment Alternatives to Relieve Adolescent Depression (STAR-AD): a Pragmatic Clinical Trial
Who cites it
77 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- A systematic review of therapeutic ketamine use in children and adolescents with treatment-resistant mood disorders.European child & adolescent psychiatry · 2021Pooled it
- A systematic review of interventions for treatment resistant major depressive disorder in adolescents.European child & adolescent psychiatry · 2020Pooled it
- Antidepressant Treatment Duration in Pediatric Depressive and Anxiety Disorders: How Long is Long Enough?Current problems in pediatric and adolescent health care · 2018Pooled it
- Treatment for paediatric chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) and comorbid depression: a systematic review.BMJ open · 2016Pooled it
- Comorbid Anxiety and Depressive Symptoms in Children and Adolescents: A Systematic Review and Analysis.Journal of psychiatric practice · 2016Pooled it
- Psychological therapies versus antidepressant medication, alone and in combination for depression in children and adolescents.The Cochrane database of systematic reviews · 2014Pooled it
- Interventions for preventing relapse and recurrence of a depressive disorder in children and adolescents.The Cochrane database of systematic reviews · 2012Pooled it
- Use of a Medication Management Algorithm in Depressed Youth Living with HIV: Secondary Analysis of a Multisite Randomized Controlled Trial.Journal of child and adolescent psychopharmacology · 2026Trial
- Vortioxetine in children and adolescents with major depressive disorder: 6-month and 18-month open-label, flexible-dose, long-term extension studies.European child & adolescent psychiatry · 2025Trial
- Site-Randomized Controlled Trial of a Combined Cognitive Behavioral Therapy and a Medication Management Algorithm for Treatment of Depression Among Youth Living With HIV in the United States.Journal of acquired immune deficiency syndromes (1999) · 2021Trial
- Left prefrontal transcranial magnetic stimulation for treatment-resistant depression in adolescents: a double-blind, randomized, sham-controlled trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Trial
- A Randomized, Double-Blind, Placebo-Controlled Trial of Vilazodone in Children and Adolescents with Major Depressive Disorder with Twenty-Six-Week Open-Label Follow-Up.Journal of child and adolescent psychopharmacology · 2020Trial
- Pilot Randomized Controlled Trial of Omega-3 and Individual-Family Psychoeducational Psychotherapy for Children and Adolescents With Depression.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53 · 2019Trial
- Understanding the Impact of Treatment on the Dimensions of Childhood Depression.Journal of child and adolescent psychopharmacology · 2017Trial
- Effective Treatment of Depressive Disorders in Medical Clinics for Adolescents and Young Adults Living With HIV: A Controlled Trial.Journal of acquired immune deficiency syndromes (1999) · 2016Trial
- Treatment moderators of child- and family-focused cognitive-behavioral therapy for pediatric bipolar disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2015Trial
- Childhood depression subscales using repeated sessions on Children's Depression Rating Scale - revised (CDRS-R) scores.Journal of child and adolescent psychopharmacology · 2014Trial
- 24- and 36-week outcomes for the Child/Adolescent Anxiety Multimodal Study (CAMS).Journal of the American Academy of Child and Adolescent Psychiatry · 2014Trial
- Predictors and moderators in the randomized trial of multifamily psychoeducational psychotherapy for childhood mood disorders.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53 · 2014Trial
- The bidirectional relationship between body mass index and treatment outcome in adolescents with treatment-resistant depression.Journal of child and adolescent psychopharmacology · 2013Trial
17 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
19 authors.
Funding
Abstract
objectiveThe purpose of this study was to report on the outcome of participants in the Treatment of Resistant Depression in Adolescents (TORDIA) trial after 24 weeks of treatment, including remission and relapse rates and predictors of treatment outcome.
methodAdolescents (ages 12-18 years) with selective serotonin reuptake inhibitor (SSRI)-resistant depression were randomly assigned to either a medication switch alone (alternate SSRI or venlafaxine) or a medication switch plus cognitive-behavioral therapy (CBT). At week 12, responders could continue in their assigned treatment arm and nonresponders received open treatment (medication and/or CBT) for 12 more weeks (24 weeks total). The primary outcomes were remission and relapse, defined by the Adolescent Longitudinal Interval Follow-Up Evaluation as rated by an independent evaluator.
resultsOf 334 adolescents enrolled in the study, 38.9% achieved remission by 24 weeks, and initial treatment assignment did not affect rates of remission. Likelihood of remission was much higher (61.6% versus 18.3%) and time to remission was much faster among those who had already demonstrated clinical response by week 12. Remission was also higher among those with lower baseline depression, hopelessness, and self-reported anxiety. At week 12, lower depression, hopelessness, anxiety, suicidal ideation, family conflict, and absence of comorbid dysthymia, anxiety, and drug/alcohol use and impairment also predicted remission. Of those who responded by week 12, 19.6% had a relapse of depression by week 24.
conclusionsContinued treatment for depression among treatment-resistant adolescents results in remission in approximately one-third of patients, similar to adults. Eventual remission is evident within the first 6 weeks in many, suggesting that earlier intervention among nonresponders could be important.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.