ArticleHeart (British Cardiac Society)2010
Cotinine-assessed second-hand smoke exposure and risk of cardiovascular disease in older adults.
Article in Heart (British Cardiac Society), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Passive smoking as a risk factor for dementia and cognitive impairment: systematic review of observational studies.International psychogeriatrics · 2018Pooled it
- Meta-analysis of the association between second-hand smoke exposure and ischaemic heart diseases, COPD and stroke.BMC public health · 2015Pooled it
- Pooled it
- Trial
- Secondhand smoke exposure and resting heart rate in young US adults: analysis of NHANES 2013-2018.Proceedings (Baylor University. Medical Center) · 2026Article
- Blood concentrations of volatile organic compounds and hypertension in the GuLF Study.The Science of the total environment · 2025Article
- Secondhand smoke exposure is independently associated with stroke among non-smoking adults in West Africa.Journal of the neurological sciences · 2022Article
- Prenatal phthalate exposure and early childhood wheeze in the SELMA study.Journal of exposure science & environmental epidemiology · 2022Article
- The combined chemical and mechanical modifications of cigarette: a novel methodology to reduce harmful effects.Environmental science and pollution research international · 2021Article
- Environmental exposures and sleep outcomes: A review of evidence, potential mechanisms, and implications.Environmental research · 2021Review
- Phthalate levels in indoor dust and associations to croup in the SELMA study.Journal of exposure science & environmental epidemiology · 2021Article
- Smoking habits and incidence of cardiovascular diseases in men and women: findings of a 12 year follow up among an urban Eastern-Mediterranean population.BMC public health · 2019Article
- Association of secondhand tobacco smoke exposure during childhood on adult cardiovascular disease risk among never-smokers.Annals of epidemiology · 2019Article
- Incorporating regulatory guideline values in analysis of epidemiology data.Environment international · 2018Article
- Temporal trends of phthalate exposures during 2007-2010 in Swedish pregnant women.Journal of exposure science & environmental epidemiology · 2018Article
- Prenatal Bisphenol A Exposure is Linked to Epigenetic Changes in Glutamate Receptor Subunit Gene Grin2b in Female Rats and Humans.Scientific reports · 2018Article
- Secondhand smoke exposure and risk of incident peripheral arterial disease and mortality: a Scotland-wide retrospective cohort study of 4045 non-smokers with cotinine measurement.BMC public health · 2018Article
- Environmental Tobacco Smoke Exposure at Home and High-Sensitivity C-Reactive Protein Levels in Three-to-Five-Year-Old Children.International journal of environmental research and public health · 2017Article
- Effect of smoking status on coronary artery disease among Chinese post-menopausal women.Internal and emergency medicine · 2016Observational
- Secondhand Smoke Exposure and Stroke: The Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study.American journal of preventive medicine · 2015Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesTo examine whether second-hand smoke (SHS) exposure measured by serum cotinine is associated with increased coronary heart disease (CHD) and stroke risk among contemporary older British adults.
designProspective population-based study with self-reported medical history and health behaviours. Fasting blood samples were analysed for serum cotinine and cardiovascular disease (CVD) risk markers.
settingPrimary care centres in 25 British towns in 1998-2001. PATIENTS: 8512 60-79-year-old men and women selected from primary care registers.
main outcome measuresFatal and non-fatal myocardial infarction (MI; n=445) and stroke (n=386) during median 7.8-year follow-up. MAIN EXPOSURE: Observational study of serum cotinine assayed from fasting blood sample using liquid chromatography tandem mass spectrometry method, and self-reported smoking history.
resultsAmong 5374 non-smokers without pre-existing CVD, geometric mean cotinine was 0.15 ng/ml (IQR 0.05-0.30). Compared with non-smokers with cotinine < or =0.05 ng/ml, higher cotinine levels (0.06-0.19, 0.2-0.7 and 0.71-15.0 ng/ml) showed little association with MI; adjusted HRs were 0.92 (95% CI 0.63 to 1.35), 1.07 (0.73 to 1.55) and 1.09 (0.69 to 1.72), p(trend)=0.69. Equivalent HRs for stroke were 0.82 (0.55 to 1.23), 0.74 (0.48 to 1.13) and 0.69 (0.41 to 1.17), p(trend)=0.065. The adjustment for sociodemographic, behavioural and CVD risk factors had little effect on the results. The HR of MI for smokers (1-9 cigarettes/day) compared with non-smokers with cotinine < or =0.05 ng/ml was 2.14 (1.39 to 3.52) and 1.03 (0.52 to 2.04) for stroke.
conclusionsIn contemporary older men and women, SHS exposure (predominantly at low levels) was not related to CHD or stroke risks, but we cannot rule out the possibility of modest effects at higher exposure levels.
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