ArticleCell host & microbe2010
Defining a core set of actin cytoskeletal proteins critical for actin-based motility of Rickettsia.
Article in Cell host & microbe, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 67 citations in OpenAlex.
- Divergent Rickettsia species exhibit distinct mechanisms of actin-based motility.The Journal of cell biology · 2026Article
- Profilin and Its Isoforms: Unravelling the Functional Diversity Across Life Forms.Current protein & peptide science · 2026Review
- The host calcium system contributes to intracellularInfection and immunity · 2025Article
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- Metagenome diversity illuminates origins of pathogen effectors.bioRxiv : the preprint server for biology · 2023Article
- Coinfection of TwoMicrobiology spectrum · 2022Article
- Spotted Fever GroupMicrobiology spectrum · 2021Article
- Plastin 3 in health and disease: a matter of balance.Cellular and molecular life sciences : CMLS · 2021Review
- The enigmatic biology of rickettsiae: recent advances, open questions and outlook.Pathogens and disease · 2021Review
- Mitochondrion-Dependent Apoptosis Is Essential for Rickettsia parkeri Infection and Replication in Vector Cells.mSystems · 2021Article
- Recent research milestones in the pathogenesis of human rickettsioses and opportunities ahead.Future microbiology · 2020Review
- Cutaneous Immunoprofiles of Three Spotted Fever Group Rickettsia Cases.Infection and immunity · 2020Article
- Baculovirus Actin-Based Motility Drives Nuclear Envelope Disruption and Nuclear Egress.Current biology : CB · 2018Article
- In vitro studies of Rickettsia-host cell interactions: Confocal laser scanning microscopy of Rickettsia helvetica-infected eukaryotic cell lines.PLoS neglected tropical diseases · 2018Article
- Review
- A streamlined method for transposon mutagenesis of Rickettsia parkeri yields numerous mutations that impact infection.PloS one · 2018Article
- MicroRNA Signature of Human Microvascular Endothelium Infected with Rickettsia rickettsii.International journal of molecular sciences · 2017Article
- Actin-based motility and cell-to-cell spread of bacterial pathogens.Current opinion in microbiology · 2017Review
- Microbial Invasion vs. Tick Immune Regulation.Frontiers in cellular and infection microbiology · 2017Review
- Secretome of obligate intracellular Rickettsia.FEMS microbiology reviews · 2015Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Many Rickettsia species are intracellular bacterial pathogens that use actin-based motility for spread during infection. However, while other bacteria assemble actin tails consisting of branched networks, Rickettsia assemble long parallel actin bundles, suggesting the use of a distinct mechanism for exploiting actin. To identify the underlying mechanisms and host factors involved in Rickettsia parkeri actin-based motility, we performed an RNAi screen targeting 115 actin cytoskeletal genes in Drosophila cells. The screen delineated a set of four core proteins-profilin, fimbrin/T-plastin, capping protein, and cofilin--as crucial for determining actin tail length, organizing filament architecture, and enabling motility. In mammalian cells, these proteins were localized throughout R. parkeri tails, consistent with a role in motility. Profilin and fimbrin/T-plastin were critical for the motility of R. parkeri but not Listeria monocytogenes. Our results highlight key distinctions between the evolutionary strategies and molecular mechanisms employed by bacterial pathogens to assemble and organize actin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.