ReviewGastroenterology clinics of North America2010
Targets for current pharmacologic therapy in cholesterol gallstone disease.
Review in Gastroenterology clinics of North America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 64 citations in OpenAlex.
- Functional fatty acid-based dietary therapy as a new strategy for small gallstone expulsion: study protocol for a prospective, single-center, double-blind, randomized controlled trial.Frontiers in nutrition · 2026Article
- Single-Session Percutaneous Cholangioscopy for High-Risk Patients with Biliary Stone Disease.Cardiovascular and interventional radiology · 2026Article
- Association of Metabolic Syndrome and Cholelithiasis: Understanding the Underlying Mechanism for Better Treatment.Mini reviews in medicinal chemistry · 2026Review
- Cholecystitis with gallbladder rupture leading to free gallstone migration causing chronic abdominal wall sinus formation: A case report.World journal of gastrointestinal surgery · 2025Article
- Article
- FXR Signaling-Mediated Bile Acid Metabolism Is Critical for Alleviation of Cholesterol Gallstones byMicrobiology spectrum · 2022Article
- Effect and related mechanism of Yinchenhao decoction on mice with lithogenic diet-induced cholelithiasis.Experimental and therapeutic medicine · 2021Article
- Cholecystectomy is Feasible in Children with Small-Sized or Large Numbers of Gallstones and in Those with Persistent Symptoms Despite Medical Treatment.Pediatric gastroenterology, hepatology & nutrition · 2020Article
- Similarities and differences between biliary sludge and microlithiasis: Their clinical and pathophysiological significances.Liver research (Beijing, China) · 2018Article
- Recent advances in understanding and managing cholesterol gallstones.F1000Research · 2018Review
- New insights into the role ofLiver research (Beijing, China) · 2017Article
- Effects of sphincter of Oddi motility on the formation of cholesterol gallstones.World journal of gastroenterology · 2016Article
- Organochloride pesticides induced hepatic ABCG5/G8 expression and lipogenesis in Chinese patients with gallstone disease.Oncotarget · 2016Article
- Gallstones: new insights into an old story.F1000Research · 2016Review
- A novel therapeutic effect of statins on nephrogenic diabetes insipidus.Journal of cellular and molecular medicine · 2015Review
- Helicobacter pylori infection is positively associated with gallstones: a large-scale cross-sectional study in Japan.Journal of gastroenterology · 2014Article
- High rates of recurrent biliary tract obstruction in children with sickle cell disease.Pediatric blood & cancer · 2013Article
- Therapy of gallstone disease: What it was, what it is, what it will be.World journal of gastrointestinal pharmacology and therapeutics · 2012Article
- Ezetimibe: its novel effects on the prevention and the treatment of cholesterol gallstones and nonalcoholic Fatty liver disease.Journal of lipids · 2012Article
- Antilithiasic and hypolipidaemic effects of Raphanus sativus L. var. niger on mice fed with a lithogenic diet.Journal of biomedicine & biotechnology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Gallstone disease is a frequent condition throughout the world and, cholesterol stones are the most frequent form in Western countries. The standard treatment of symptomatic gallstone subjects is laparoscopic cholecystectomy. The selection of patients amenable for nonsurgical, medical therapy is of key importance; a careful analysis should consider the natural history of the disease and the overall costs of therapy. Only patients with mild symptoms and small, uncalcified cholesterol gallstones in a functioning gallbladder with a patent cystic duct are considered for oral litholysis by hydrophilic ursodeoxycholic acid, in the hope of achieving cholesterol desaturation of bile and progressive stone dissolution. Recent studies have raised the possibility that cholesterol-lowering agents that inhibit hepatic cholesterol synthesis (statins) or intestinal cholesterol absorption (ezetimibe), or drugs acting on specific nuclear receptors involved in cholesterol and bile acid homeostasis, may offer, alone or in combination, additional medical therapeutic tools for treating cholesterol gallstones. Recent perspectives on medical treatment of cholesterol gallstone disease are discussed in this article.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.