ArticleBehavioural brain research2010
Temporal ordering deficits in female CGG KI mice heterozygous for the fragile X premutation.
Article in Behavioural brain research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 54 citations in OpenAlex.
- High-Fat Diet Consumption Induces Neurobehavioral Abnormalities and Neuronal Morphological Alterations Accompanied by Excessive Microglial Activation in the Medial Prefrontal Cortex in Adolescent Mice.International journal of molecular sciences · 2023Article
- Impaired adult hippocampal neurogenesis in a mouse model of familial hypercholesterolemia: A role for the LDL receptor and cholesterol metabolism in adult neural precursor cells.Molecular metabolism · 2019Article
- Astroglial-targeted expression of the fragile X CGG repeat premutation in mice yields RAN translation, motor deficits and possible evidence for cell-to-cell propagation of FXTAS pathology.Acta neuropathologica communications · 2019Article
- Of Men and Mice: Modeling the Fragile X Syndrome.Frontiers in molecular neuroscience · 2018Article
- Adaptation of the Arizona Cognitive Task Battery for use with the Ts65Dn mouse model (Mus musculus) of Down syndrome.Journal of comparative psychology (Washington, D.C. : 1983) · 2017Article
- Calcium dysregulation and Cdk5-ATM pathway involved in a mouse model of fragile X-associated tremor/ataxia syndrome.Human molecular genetics · 2017Article
- Implications of thePediatrics · 2017Review
- What has been learned from mouse models of the Fragile X Premutation and Fragile X-associated tremor/ataxia syndrome?The Clinical neuropsychologist · 2016Review
- GluN2A-/- Mice Lack Bidirectional Synaptic Plasticity in the Dentate Gyrus and Perform Poorly on Spatial Pattern Separation Tasks.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Temporal dynamics of attentional selection in adult male carriers of the fragile X premutation allele and adult controls.Frontiers in human neuroscience · 2015Article
- Fragile X spectrum disorders.Intractable & rare diseases research · 2014Review
- Eye movements reveal impaired inhibitory control in adult male fragile X premutation carriers asymptomatic for FXTAS.Neuropsychology · 2014Article
- CNS expression of murine fragile X protein (FMRP) as a function of CGG-repeat size.Human molecular genetics · 2014Article
- Altered neural activity in the 'when' pathway during temporal processing in fragile X premutation carriers.Behavioural brain research · 2014Article
- Reduced activity-dependent protein levels in a mouse model of the fragile X premutation.Neurobiology of learning and memory · 2014Article
- Induced expression of expanded CGG RNA causes mitochondrial dysfunction in vivo.Cell cycle (Georgetown, Tex.) · 2014Article
- Fragile X-associated tremor/ataxia syndrome (FXTAS): pathology and mechanisms.Acta neuropathologica · 2013Review
- Neurocognitive endophenotypes in CGG KI and Fmr1 KO mouse models of Fragile X-Associated disorders: an analysis of the state of the field.F1000Research · 2013Review
- CGG trinucleotide repeat length modulates neural plasticity and spatiotemporal processing in a mouse model of the fragile X premutation.Hippocampus · 2012Article
- Young adult male carriers of the fragile X premutation exhibit genetically modulated impairments in visuospatial tasks controlled for psychomotor speed.Journal of neurodevelopmental disorders · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The fragile X premutation is a tandem CGG trinucleotide repeat expansion on the FMR1 gene between 55 and 200 repeats in length. A CGG knock-in (CGG KI) mouse with CGG repeat lengths between 70 and 350 has been developed and used to characterize the histopathology and cognitive deficits reported in carriers of the fragile X premutation. Previous studies have shown that CGG KI mice show progressive deficits in processing spatial information. To further characterize cognitive deficits in the fragile X premutation, temporal ordering in CGG knock-in (CGG KI) mice was evaluated. Female CGG KI mice were tested for their ability to remember the temporal order in which two objects were presented. The results demonstrate that at 48 weeks of age, female CGG KI mice with CGG repeat expansions between 150 and 200 CGG repeats performed more poorly on tests of temporal order than wildtype mice, whereas female CGG KI mice with between 80 and 100 CGG repeats performed similarly to wildtype mice. No mice had any difficulty in detecting the presence of a novel object. These data suggest female CGG KI mice show a CGG repeat length-sensitive deficit for temporal ordering.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.