ArticleExperimental neurology2010
Dendritic alterations after dynamic axonal stretch injury in vitro.
Article in Experimental neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
- Mechanobiological insight into brain diseases based on mechanosensitive channels: Common mechanisms and clinical potential.CNS neuroscience & therapeutics · 2024Review
- Temporal and structural sensitivities of major biomarkers for detecting neuropathology after traumatic brain injury in the mouse.Frontiers in neuroscience · 2024Article
- HIV-1 envelope protein gp120 modulation of glutamate effects on cortical neuronal synapses: implications for HIV-1-associated neuropathogenesis.International journal of physiology, pathophysiology and pharmacology · 2023Article
- Dorsal root ganglion neurons recapitulate the traumatic axonal injury of CNS neurons in response to a rapid stretchFrontiers in cellular neuroscience · 2023Article
- Low-intensity blast induces acute glutamatergic hyperexcitability in mouse hippocampus leading to long-term learning deficits and altered expression of proteins involved in synaptic plasticity and serine protease inhibitors.Neurobiology of disease · 2022Article
- Characterisation of Severe Traumatic Brain Injury Severity from Fresh Cerebral Biopsy of Living Patients: An Immunohistochemical Study.Biomedicines · 2022Article
- Amyloidogenic Processing of Amyloid Precursor Protein Drives Stretch-Induced Disruption of Axonal Transport in hiPSC-Derived Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- The Emergence of Model Systems to Investigate the Link Between Traumatic Brain Injury and Alzheimer's Disease.Frontiers in aging neuroscience · 2021Review
- Mechanosensation in traumatic brain injury.Neurobiology of disease · 2021Review
- Characterization of neurite dystrophy after trauma by high speed structured illumination microscopy and lattice light sheet microscopy.Journal of neuroscience methods · 2019Article
- Mild and repetitive very mild axonal stretch injury triggers cystoskeletal mislocalization and growth cone collapse.PloS one · 2017Article
- Synaptic Mechanisms of Blast-Induced Brain Injury.Frontiers in neurology · 2016Review
- Effects of Repetitive Transcranial Magnetic Stimulation on Behavioral Recovery during Early Stage of Traumatic Brain Injury in Rats.Journal of Korean medical science · 2015Article
- Microfluidic culture platform for studying neuronal response to mild to very mild axonal stretch injury.Biomicrofluidics · 2014Article
- Neural circuits with long-distance axon tracts for determining functional connectivity.Journal of neuroscience methods · 2014Article
- Axonal pathology in traumatic brain injury.Experimental neurology · 2013Review
- Mathematical Models of Blast-Induced TBI: Current Status, Challenges, and Prospects.Frontiers in neurology · 2013Article
- Coupled left-shift of Nav channels: modeling the Na⁺-loading and dysfunctional excitability of damaged axons.Journal of computational neuroscience · 2012Article
- Use-dependent dendritic regrowth is limited after unilateral controlled cortical impact to the forelimb sensorimotor cortex.Journal of neurotrauma · 2012Article
- Traumatic alterations in GABA signaling disrupt hippocampal network activity in the developing brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Traumatic axonal injury (TAI) is the most common and important pathology of traumatic brain injury (TBI). However, little is known about potential indirect effects of TAI on dendrites. In this study, we used a well-established in vitro model of axonal stretch injury to investigate TAI-induced changes in dendrite morphology. Axons bridging two separated rat cortical neuron populations plated on a deformable substrate were used to create a zone of isolated stretch injury to axons. Following injury, we observed the formation of dendritic alterations or beading along the dendrite shaft. Dendritic beading formed within minutes after stretch then subsided over time. Pharmacological experiments revealed a sodium-dependent mechanism, while removing extracellular calcium exacerbated TAI's effect on dendrites. In addition, blocking ionotropic glutamate receptors with the N-methyl-d-aspartate (NMDA) receptor antagonist MK-801 prevented dendritic beading. These results demonstrate that axon mechanical injury directly affects dendrite morphology, highlighting an important bystander effect of TAI. The data also imply that TAI may alter dendrite structure and plasticity in vivo. An understanding of TAI's effect on dendrites is important since proper dendrite function is crucial for normal brain function and recovery after injury.
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Registered trials
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