ArticleCell2010
The vomeronasal organ mediates interspecies defensive behaviors through detection of protein pheromone homologs.
Article in Cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 176 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
176 citing papers in PubMed, 375 citations in OpenAlex.
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- Bile acid chemosensation in mammals supports species and gut microbiome evaluation.bioRxiv : the preprint server for biology · 2026Article
- Olfactory immunity: defending the neural-mucosal barrier.Journal of immunology (Baltimore, Md. : 1950) · 2026Review
- Divergent prefrontal cortex circuits regulate cued food seeking under distinct metabolic or emotional states.Nature communications · 2025Article
- CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Evolutionary Process Underlying Receptor Gene Expansion and Cellular Divergence of Olfactory Sensory Neurons in Honeybees.Molecular biology and evolution · 2025Article
- Behavioral Assays in the Study of Olfaction.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Behavioral and neurobiological implications of kairomones for rodents: an updated review.Frontiers in neuroscience · 2025Review
- Stem cell expression of CXCR4 regulates tissue composition in the vomeronasal organ.Journal of cell science · 2025Article
- The Accessory Olfactory Bulb inAnimals : an open access journal from MDPI · 2024Article
- Hypothalamic representation of the imminence of predator threat detected by the vomeronasal organ in mice.eLife · 2024Article
- Allergies to Allergens from Cats and Dogs: A Review and Update on Sources, Pathogenesis, and Strategies.International journal of molecular sciences · 2024Review
- Prior Negative Experience Biases Activity of Medial Amygdala during Interstrain Social Engagement in Male Rats.eNeuro · 2024Article
- Species recognition and the divergences in the chemical and ultrasonic signals between two coexistingCurrent zoology · 2024Article
- Article
- Traumatic stress-enhanced alcohol drinking: Sex differences and animal model perspectives.Current addiction reports · 2024Article
- Following the p63/Keratin5 basal cells in the sensory and non-sensory epithelia of the vomeronasal organ.Genesis (New York, N.Y. : 2000) · 2024Article
- Type 2 vomeronasal receptor-A4 subfamily: Potential predator sensors in mice.Genesis (New York, N.Y. : 2000) · 2024Review
- Connectivity and molecular profiles of Foxp2- and Dbx1-lineage neurons in the accessory olfactory bulb and medial amygdala.The Journal of comparative neurology · 2024Article
- Harnessing the potential of the NALT and BALT as targets for immunomodulation using engineering strategies to enhance mucosal uptake.Frontiers in immunology · 2024Review
116 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Potential predators emit uncharacterized chemosignals that warn receiving species of danger. Neurons that sense these stimuli remain unknown. Here we show that detection and processing of fear-evoking odors emitted from cat, rat, and snake require the function of sensory neurons in the vomeronasal organ. To investigate the molecular nature of the sensory cues emitted by predators, we isolated the salient ligands from two species using a combination of innate behavioral assays in naive receiving animals, calcium imaging, and c-Fos induction. Surprisingly, the defensive behavior-promoting activity released by other animals is encoded by species-specific ligands belonging to the major urinary protein (Mup) family, homologs of aggression-promoting mouse pheromones. We show that recombinant Mup proteins are sufficient to activate sensory neurons and initiate defensive behavior similarly to native odors. This co-option of existing sensory mechanisms provides a molecular solution to the difficult problem of evolving a variety of species-specific molecular detectors.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.