Viral defense: it takes two MAVS to Tango.

Shruti Sharma, Katherine A Fitzgerald

Open access · bronzeAbstract readComment

In one paragraph

Article in Cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it

0cells of the map it votes in

7citing papers in PubMed

0.7field-weighted citation impact, top 31% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

Impaired Mitochondrial Function in T-Lymphocytes as a Result of Exposure to HIV and ART.Cells · 2023
Review
The inducible amphisome isolates viral hemagglutinin and defends against influenza A virus infection.Nature communications · 2020
Article
The pestivirus N terminal protease N(pro) redistributes to mitochondria and peroxisomes suggesting new sites for regulation of IRF3 by N(pro.).PloS one · 2014
Article
Alterations of immune response of Non-Small Cell Lung Cancer with Azacytidine.Oncotarget · 2013
Article
Poly(C)-binding protein 1 (PCBP1) mediates housekeeping degradation of mitochondrial antiviral signaling (MAVS).Cell research · 2012
Article
Hepatitis B virus regulatory HBx protein binds to adaptor protein IPS-1 and inhibits the activation of beta interferon.Journal of virology · 2011
Article
Function and regulation of retinoic acid-inducible gene-I.Critical reviews in immunology · 2010
Review

4 · The record

Corrections and comments

Comment on
Peroxisomes are signaling platforms for antiviral innate immunity.2010

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Shruti SharmaDivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.

Katherine A Fitzgerald

University of Massachusetts Chan Medical School · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To defend cells against viruses, the MAVS (mitochondrial antiviral signaling) adaptor protein initiates an antiviral signaling cascade from mitochondrial membranes. In this issue, Dixit et al. (2010) show that MAVS also localizes to the membranes of peroxisomes, where it rapidly induces expression of a subset of antiviral genes that curb viral replication until mitochondrial MAVS can induce a sustained antiviral response.

Identifiers

PMID20478250

DOI10.1016/j.cell.2010.04.043

OpenAlexW1990646772

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.