ArticleBMC medical genetics2010
LINE-1 methylation is inherited in familial testicular cancer kindreds.
Article in BMC medical genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- LINE-1 hypomethylation in blood and tissue samples as an epigenetic marker for cancer risk: a systematic review and meta-analysis.PloS one · 2014Pooled it
- Exploring transposable elements: new horizons in cancer diagnostics and therapeutics.Mobile DNA · 2025Review
- A multi-analyte liquid biopsy approach for nonseminomatous testicular germ cell tumors: combining cfDNA and N-glycan analysis in blood and seminal plasma.Cancer cell international · 2025Article
- Article
- One-carbon metabolism and global DNA methylation in mothers of individuals with Down syndrome.Human cell · 2021Article
- Review
- Epigenome-based cancer risk prediction: rationale, opportunities and challenges.Nature reviews. Clinical oncology · 2018Review
- Article
- Global methylation of blood leukocyte DNA and risk of melanoma.International journal of cancer · 2017Article
- Relationships between Global DNA Methylation in Circulating White Blood Cells and Breast Cancer Risk Factors.Journal of cancer epidemiology · 2017Review
- Parent-of-origin effects of A1CF and AGO2 on testicular germ-cell tumors, testicular abnormalities, and fertilization bias.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Genomic DNA Hypomethylation and Risk of Renal Cell Carcinoma: A Case-Control Study.Clinical cancer research : an official journal of the American Association for Cancer Research · 2016Article
- New Progress of Epigenetic Biomarkers in Urological Cancer.Disease markers · 2016Review
- Paternal age and mental health of offspring.Fertility and sterility · 2015Review
- Ex vivo expansion of human mobilized peripheral blood stem cells using epigenetic modifiers.Transfusion · 2015Article
- DNA Methylation and Flavonoids in Genitourinary Cancers.Current pharmacology reports · 2015Article
- LINE1 methylation levels in pre-diagnostic leukocyte DNA and future renal cell carcinoma risk.Epigenetics · 2015Article
- Clinical implications of the LINE-1 methylation levels in patients with gastrointestinal cancer.Surgery today · 2014Review
- Familial testicular germ cell tumor: no associated syndromic pattern identified.Hereditary cancer in clinical practice · 2014Article
- Differences in DNA methylation by extent of breast cancer family history in unaffected women.Epigenetics · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundTesticular germ cell tumors (TGCT) are the most frequent cancers among young men. There is a clear familial component to TGCT etiology, but no high-penetrance susceptibility gene has been identified. Epigenetic aberrations of the genome represent an alternative mechanism for cancer susceptibility; and, studies suggest that epigenetic changes that influence cancer risk can be inherited through the germline. Global DNA hypomethylation has been associated with the risk of cancers of the bladder and head/neck.
methodsWe performed a pilot study of global methylation at long interspersed nuclear elements-1 (LINE-1) in peripheral blood DNA isolated from 466 family members of 101 multiple-case testicular cancer families.
resultsInvestigating the correlation of LINE-1 methylation levels among parent-child pairs independent of affection status (n = 355) revealed a strong positive association only between mother-daughter (r = 0.48, P = <0.001) and father-daughter pairs (r = 0.31, P = 0.02), suggesting gender-specific inheritance of methylation. Incorporating cancer status, we observed a strong correlation in LINE-1 methylation levels only among affected father-affected son pairs (r = 0.49, P = 0.03). There was a marginally significant inverse association between lower LINE-1 methylation levels and increased TGCT risk, compared with healthy male relatives (P = 0.049).
conclusionsOur data suggest that heritability of LINE-1 methylation may be gender-specific. Further, the strong correlation between LINE-1 methylation levels among affected father-affected son pairs suggests that transgenerational inheritance of an epigenetic event may be associated with disease risk. Larger studies are needed to clarify these preliminary observations.
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