ReviewScandinavian journal of trauma, resuscitation and emergency medicine2010
A review of metabolic staging in severely injured patients.
Review in Scandinavian journal of trauma, resuscitation and emergency medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 39 citations in OpenAlex.
- Hallmarks of the multidimensional immune response to trauma in humans.Nature immunology · 2026Review
- Multiple portions enteral nutrition and chyme reinfusion of a blunt bowel injury patient with hyperbilirubinemia undergoing open abdomen: A case report.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2023Article
- Carcinogenesis: the cancer cell-mast cell connection.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2019Review
- Metabolomics of trauma-associated death: shared and fluid-specific features of human plasma vs lymph.Blood transfusion = Trasfusione del sangue · 2016Article
- Elevated Serum Insulin-Like Growth Factor 1 Levels in Patients with Neurological Remission after Traumatic Spinal Cord Injury.PloS one · 2016Article
- Trauma/hemorrhagic shock instigates aberrant metabolic flux through glycolytic pathways, as revealed by preliminary (13)C-glucose labeling metabolomics.Journal of translational medicine · 2015Article
- Early hemorrhage triggers metabolic responses that build up during prolonged shock.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Continuous hemodiafiltration therapy reduces damage of multi-organs by ameliorating of HMGB1/TLR4/NFκB in a dog sepsis model.International journal of clinical and experimental pathology · 2015Article
- The role of physiological elements in the future therapies of rheumatoid arthritis. II. The relevance of energy redistribution in the process of chronic inflammation.Reumatologia · 2015Article
- Mitochondrial DNA induces inflammation and increases TLR9/NF-κB expression in lung tissue.International journal of molecular medicine · 2014Article
- The role of diminishing appetite and serum nesfatin-1 level in patients with burn wound infection.Iranian Red Crescent medical journal · 2013Article
- Surgical inflammatory stress: the embryo takes hold of the reins again.Theoretical biology & medical modelling · 2013Review
- Metabolomic fingerprinting: challenges and opportunities.Critical reviews in biomedical engineering · 2013Review
- The role of high-mobility group box-1 (HMGB-1) in the management of suspected acute appendicitis: useful diagnostic biomarker or just another blind alley?Scandinavian journal of trauma, resuscitation and emergency medicine · 2011Article
- "Metabolic staging" after major trauma - a guide for clinical decision making?Scandinavian journal of trauma, resuscitation and emergency medicine · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An interpretation of the metabolic response to injury in patients with severe accidental or surgical trauma is made. In the last century, various authors attributed a meaning to the post-traumatic inflammatory response by using teleological arguments. Their interpretations of this response, not only facilitates integrating the knowledge, but also the flow from the bench to the bedside, which is the main objective of modern translational research. The goal of the current review is to correlate the metabolic changes with the three phenotypes -ischemia-reperfusion, leukocytic and angiogenic- that the patients express during the evolution of the systemic inflammatory response. The sequence in the expression of multiple metabolic systems that becomes progressively more elaborate and complex in severe injured patients urges for more detailed knowledge in order to establish the most adequate metabolic support according to the evolutive phase. Thus, clinicians must employ different treatment strategies based on the different metabolic phases when caring for this challenging patient population. Perhaps, the best therapeutic option would be to favor early hypometabolism during the ischemia-reperfusion phase, to boost the antienzymatic metabolism and to reduce hypermetabolism during the leukocytic phase through the early administration of enteral nutrition and the modulation of the acute phase response. Lastly, the early epithelial regeneration of the injured organs and tissues by means of an oxidative metabolism would reduce the fibrotic sequelae in these severely injured patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.