ArticleAlcoholism, clinical and experimental research2010
ADH1B*3 and response to alcohol in African-Americans.
Article in Alcoholism, clinical and experimental research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Review
- The Genetically Informed Neurobiology of Addiction (GINA) model.Nature reviews. Neuroscience · 2023Review
- A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity.Alcoholism, clinical and experimental research · 2018Review
- The Relationship between Alcohol Drinking Patterns and Sleep Duration among Black and White Men and Women in the United States.International journal of environmental research and public health · 2018Article
- ADH1B: From alcoholism, natural selection, and cancer to the human phenome.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2018Review
- Interaction between the ADH1B*3 allele and drinking motives on alcohol use among Black college students.The American journal of drug and alcohol abuse · 2018Article
- The association between alcohol abuse and neuroendocrine system dysregulation: Race differences in a National sample.Brain, behavior, and immunity · 2017Article
- Interaction between ADH1B*3 and alcohol-facilitating social environments in alcohol behaviors among college students of african descent.The American journal on addictions · 2017Article
- The Genetics of Fetal Alcohol Spectrum Disorders.Alcoholism, clinical and experimental research · 2016Review
- Interactions Between Alcohol Metabolism Genes and Religious Involvement in Association With Maximum Drinks and Alcohol Dependence Symptoms.Journal of studies on alcohol and drugs · 2016Article
- Biology, Genetics, and Environment: Underlying Factors Influencing Alcohol Metabolism.Alcohol research : current reviews · 2016Review
- Black-White differences in the relationship between alcohol drinking patterns and mortality among US men and women.American journal of public health · 2015Article
- Association and ancestry analysis of sequence variants in ADH and ALDH using alcohol-related phenotypes in a Native American community sample.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2014Article
- Subjective response to alcohol and ADH polymorphisms in a select sample of young adult male East Indians and Africans in Trinidad and Tobago.Journal of studies on alcohol and drugs · 2014Article
- Genetic influences on response to alcohol and response to pharmacotherapies for alcoholism.Pharmacology, biochemistry, and behavior · 2014Review
- Less drinking, yet more problems: understanding African American drinking and related problems.Psychological bulletin · 2014Review
- Evaluation of the influence of alcohol dehydrogenase polymorphisms on alcohol elimination rates in African Americans.Alcoholism, clinical and experimental research · 2014Article
- Human laboratory paradigms in alcohol research.Alcoholism, clinical and experimental research · 2012Review
- Association of alcohol dehydrogenase genes with alcohol-related phenotypes in a Native American community sample.Alcoholism, clinical and experimental research · 2011Article
- Protective effects of the alcohol dehydrogenase-ADH1B*3 allele on attention and behavior problems in adolescents exposed to alcohol during pregnancy.Neurotoxicology and teratologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundVariations in the alleles for the alcohol-metabolizing enzymes have been shown to influence risk for alcohol dependence. One variant, ADH1B*3, is observed almost exclusively in populations of African ancestry and has been shown to be associated with reduced rates of alcohol dependence. We conducted an alcohol challenge study to test whether ADH1B*3 is associated with differences in subjective and physiological response to alcohol.
methodWe administered a moderate dose of alcohol (0.72 g/kg for males, 0.65 g/kg for females) to a sample of African-American young adults (n = 91; ages 21 to 26). Participants were genotyped for ADH1B, as well as additional polymorphisms that might contribute to alcohol response. Breath alcohol concentration, self-reported sedation and stimulation, and pulse rate were assessed prior to alcohol administration and for 2.5 hours following administration.
resultsADH1B*3 was associated with higher levels of sedation and a sharper increase in pulse rate immediately following alcohol consumption.
conclusionsThese findings suggest that the lower rates of alcohol dependence in those with ADH1B*3 alleles may be because of differences in alcohol response, particularly increased sedation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.