ArticleJournal of molecular histology2010
Age-related changes in nitric oxide synthase in the lateral geniculate nucleus of rats.
Article in Journal of molecular histology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 8 citations in OpenAlex.
- Excessive levels of nitric oxide in rat model of Parkinson's disease induced by rotenone.Experimental and therapeutic medicine · 2015Article
- Mitral and tufted cells are potential cellular targets of nitration in the olfactory bulb of aged mice.PloS one · 2013Article
- Alterations in nitric oxide synthase in the aged CNS.Oxidative medicine and cellular longevity · 2012Review
- Nitric oxidergic cells related to ejaculation in gerbil forebrain contain androgen receptor and respond to testosterone.The Journal of comparative neurology · 2011Article
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Authors and funding
2 authors at 2 institutions in 1 country.
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Abstract
Age-related changes in nitric oxide production in the visual system have not been well characterized. Therefore, we used staining and image-processing approaches to describe changes in levels of neuronal nitric oxide synthase (nNOS), the NADPH-diaphorase (NADPH-d) histochemical marker, and 3-nitrotyrosine in the lateral geniculate nucleus (LGN) of young and aged rats. The LGN plays an important role in the visual system, as it acts as a visual relay nucleus. Quantitative analysis of NADPH-d-positive and nNOS-immunoreactive neurons revealed significant optical density increases in the dorsal LGN and ventral LGN of aged rats; however, no significant changes were observed in the number of neurons with age. 3-Nitrotyrosine immunoreactivity was increased in the dorsal LGN and ventral LGN of aged rats. These results indicate that increased nitric oxide production and peroxynitrite may be associated with alterations in visual function during aging.
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