Evidence map›Paper›PMID 20473638›Full record

ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2010

Stress-mediated quality of life outcomes in parents of childhood cancer and brain tumor survivors: a case-control study.

Whitney P Witt, Kristin Litzelman, Lauren E Wisk, Hilary A Spear, Kris Catrine, Nataliya Levin, Carissa A Gottlieb

Abstract read
In one paragraph

Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Quality of life of primary caregivers by severity and control of children's asthma: a systematic review and meta-analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
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  5. Quality of life in pediatric oncology patients, caregivers and siblings after psychosocial screening: a randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
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  16. Assessment of health-related quality of life among parents of children with solid tumors in Serbia.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
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  19. Care burden and its predictive factors in parents of newly diagnosed children with acute lymphoblastic leukemia in academic hospitals in China.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Whitney P WittDepartment of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53792-4108, USA. wwitt@wisc.edu
Kristin Litzelman
Lauren E Wisk
Hilary A Spear
Kris Catrine
Nataliya Levin
Carissa A Gottlieb

Funding

INSTITUTIONAL CTSA (UW-MADISON): CLINICAL TRIALSUL1RR025011 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2007 to 2011
$29.5M
WISCONSIN CENTER ON MENTAL RETARDATION: CORE SUPPORTP30HD003352 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI SVAREN, JOHN P · 1985 to 2015
$25.2M
Interactions between Childhood Illness and the FamilyK01HD049533 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI WITT, WHITNEY PERKINS · 2005 to 2009
$639k
NCRR NIH HHS UL1 RR025011NICHD NIH HHS HD049533NICHD NIH HHS K01 HD049533NICHD NIH HHS P30 HD003352NICHD NIH HHS P30 HD03352
6 · The paper itself

Abstract

purposeTo determine if caring for a child with cancer or a brain tumor affects parental health and mental health and if and to what extent stress mediates the relationship between case status and parental quality of life.

methodsIn person interviewer-assisted surveys were administered to 74 case dyads (children diagnosed with cancer or a brain tumor and their parents) and 129 control dyads (children without health problems and their parents from a community sample) to assess health-related quality of life and perceived levels of stress.

resultsParents of children with cancer or a brain tumor had significantly worse health-related quality of life, including worse overall mental health. Overall physical health was no different between cases and controls. Staged multivariate analysis revealed that worse health-related quality of life is completely mediated by perceived stress in these parents.

conclusionsThe experience of caring for a child with cancer is not in itself related to poor quality of life, but is related to an increased level of stress that may adversely impact parental mental health and quality of life.

Indexed as

Stress, PsychologicalAdolescentAdultBrain NeoplasmsCaregiversCase-Control StudiesChildChild, PreschoolHumansInterviews as TopicMaleMiddle AgedParentsQuality of Life

Identifiers

PMID20473638
PMCPMC3057223

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.