ReviewPharmaceutical research2010
Vectorial ligand transport through mammalian choroid plexus.
Review in Pharmaceutical research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- Application of injectable hydrogels in the central and peripheral nervous system as a unique and flexible platform for neural tissue repair.Materials today. Bio · 2025Review
- Article
- Article
- Targeting the Choroid Plexuses for Protein Drug Delivery.Pharmaceutics · 2020Review
- A balanced evaluation of the evidence for adult neurogenesis in humans: implication for neuropsychiatric disorders.Brain structure & function · 2019Review
- Folate nutrition and blood-brain barrier dysfunction.Current opinion in biotechnology · 2017Review
- The nexus of vitamin homeostasis and DNA synthesis and modification in mammalian brain.Molecular brain · 2014Review
- Sustained choroid plexus function in human elderly and Alzheimer's disease patients.Fluids and barriers of the CNS · 2013Article
- Expression Profiling of Solute Carrier Gene Families at the Blood-CSF Barrier.Frontiers in pharmacology · 2012Article
- A novel porcine in vitro model of the blood-cerebrospinal fluid barrier with strong barrier function.PloS one · 2012Article
- Choroid plexus transport: gene deletion studies.Fluids and barriers of the CNS · 2011Article
- Roles of organic anion/cation transporters at the blood-brain and blood-cerebrospinal fluid barriers involving uremic toxins.Clinical and experimental nephrology · 2011Review
- Amyloid-beta transporter expression at the blood-CSF barrier is age-dependent.Fluids and barriers of the CNS · 2011Article
- Subcellular localization and distribution of the reduced folate carrier in normal rat tissues.European journal of histochemistry : EJH · 2011Article
- Traumatic brain injury and recovery mechanisms: peptide modulation of periventricular neurogenic regions by the choroid plexus-CSF nexus.Journal of neural transmission (Vienna, Austria : 1996) · 2011Review
- Choroid plexus failure in the Kearns-Sayre syndrome.Cerebrospinal fluid research · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the last decade, there has been substantial progress in understanding vectorial ligand transport through rodent and human choroid plexus (CP), the locus of the blood-CSF interface. In this Review, we enumerate the experimental data required to establish vectorial transport through CP and describe transporters involved in vectorial transport across CP. We also note how these transporters differ from those at the blood-brain barrier. The ligand (substrate) examples presented are methyltetrahydrofolate, methotrexate, leukotriene C(4), nucleosides, thiamine monophosphate, prostaglandins, and digoxin. Our focus is on more definitive experiments, including animal and human transporter "knock-outs." Finally, we discuss the neurochemical implications of vectorial transport through CP and the clinical implications of transporter polymorphisms and knockouts. Examples include descriptions of how vectorial transport through the CP for several micronutrients (e.g., methyltetrahydrofolate) nourishes the brain and how knowledge of CP vectorial transport can lead to important treatments.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.