ArticleMammalian genome : official journal of the International Mammalian Genome Society2010
Quantitative trait locus and haplotype mapping in closely related inbred strains identifies a locus for open field behavior.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- Prospects for finding the mechanisms of sex differences in addiction with human and model organism genetic analysis.Genes, brain, and behavior · 2020Review
- Prototypical anxiolytics do not reduce anxiety-like behavior in the open field in C57BL/6J mice.Pharmacology, biochemistry, and behavior · 2015Article
- Initial locomotor sensitivity to cocaine varies widely among inbred mouse strains.Genes, brain, and behavior · 2015Article
- A multi-megabase copy number gain causes maternal transmission ratio distortion on mouse chromosome 2.PLoS genetics · 2015Article
- A cross-species genetic analysis identifies candidate genes for mouse anxiety and human bipolar disorder.Frontiers in behavioral neuroscience · 2015Article
- Repetitive behavior profile and supersensitivity to amphetamine in the C58/J mouse model of autism.Behavioural brain research · 2014Article
- A large QTL for fear and anxiety mapped using an F2 cross can be dissected into multiple smaller QTLs.Genes, brain, and behavior · 2013Article
- Anxiety genetics - findings from cross-species genome-wide approaches.Biology of mood & anxiety disorders · 2013Article
- Accelerating discovery for complex neurological and behavioral disorders through systems genetics and integrative genomics in the laboratory mouse.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2012Review
- Forward genetic approaches to understanding complex behaviors.Current topics in behavioral neurosciences · 2012Review
- The blessings and curses of C57BL/6 substrains in mouse genetic studies.Annals of the New York Academy of Sciences · 2011Article
- The clinical implications of mouse models of enhanced anxiety.Future neurology · 2011Article
- Anxiety and fear in a cross of C57BL/6J and DBA/2J mice: mapping overlapping and independent QTL for related traits.Genes, brain, and behavior · 2011Article
- The influence of sex and estrous cycle on QTL for emotionality and ethanol consumption.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Article
- Phenotypic characterization of a genetically diverse panel of mice for behavioral despair and anxiety.PloS one · 2010Article
- Comt1 genotype and expression predicts anxiety and nociceptive sensitivity in inbred strains of mice.Genes, brain, and behavior · 2010Article
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5 authors.
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Abstract
Quantitative trait locus (QTL) mapping in the mouse typically utilizes inbred strains that exhibit significant genetic and phenotypic diversity. The development of dense SNP panels in a large number of inbred strains has eliminated the need to maximize genetic diversity in QTL studies as plenty of SNP markers are now available for almost any combination of strains. We conducted a QTL mapping experiment using both a backcross (N(2)) and an intercross (F(2)) between two genetically similar inbred mouse strains: C57BL/6J (B6) and C57L/J (C57). A set of additive QTLs for activity behaviors was identified on Chrs 1, 9, 13, and 15. We also identified additive QTLs for anxiety-related behaviors on Chrs 7, 9, and 16. A QTL on Chr 11 is sex-specific, and we revealed pairwise interactions between QTLs on Chrs 1 and 13 and Chrs 10 and 18. The Chr 9 activity QTL accounts for the largest amount of phenotypic variance and was not present in our recent analysis of a B6 x C58/J (C58) intercross (Bailey et al. in Genes Brain Behav 7:761-769, 2008). To narrow this QTL interval, we used a dense SNP haplotype map with over 7 million real and imputed SNP markers across 74 inbred mouse strains (Szatkiewicz et al. in Mamm Genome 19(3):199-208, 2008). Evaluation of shared and divergent haplotype blocks among B6, C57, and C58 strains narrowed the Chr 9 QTL interval considerably and highlights the utility of QTL mapping in closely related inbred strains.
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