ArticleCancer immunology, immunotherapy : CII2010
Inhibition of in vitro tumor cell growth by RP215 monoclonal antibody and antibodies raised against its anti-idiotype antibodies.
Article in Cancer immunology, immunotherapy : CII, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 35 citations in OpenAlex.
- Immunoglobulin G in aging and cancer.Frontiers in immunology · 2026Review
- Current insights into the expression and functions of tumor-derived immunoglobulins.Cell death discovery · 2021Review
- Upregulated Expression of Cancer-Derived Immunoglobulin G Is Associated With Progression in Glioma.Frontiers in oncology · 2021Article
- Expression of immunoglobulin G in human podocytes, and its role in cell viability and adhesion.International journal of molecular medicine · 2018Article
- Immunological and histopathological changes in sheep affected with cutaneous squamous cell carcinoma and treated immunotherapeutically.Veterinary world · 2017Article
- Aberrant high expression of immunoglobulin G in epithelial stem/progenitor-like cells contributes to tumor initiation and metastasis.Oncotarget · 2015Article
- Yeast killer toxin-like candidacidal Ab6 antibodies elicited through the manipulation of the idiotypic cascade.PloS one · 2014Article
- Program of vaccination and antibiotic treatment to control polyserositis caused by Haemophilus parasuis under field conditions.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2013Article
- CA215 and GnRH receptor as targets for cancer therapy.Cancer immunology, immunotherapy : CII · 2012Article
- Evaluation of the potency of the anti-idiotypic antibody Ab2/3H6 mimicking gp41 as an HIV-1 vaccine in a rabbit prime/boost study.PloS one · 2012Article
- Widespread expressions of immunoglobulin superfamily proteins in cancer cells.Cancer immunology, immunotherapy : CII · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RP215 monoclonal antibody (Mab) was shown to recognize carbohydrate-associated epitope(s) in the heavy chains of cancer cell-expressed immunoglobulins, designated in general as CA215 pan cancer marker. Growth inhibitions of tumor cells in vitro by RP215 Mab and antibodies against its anti-idiotype (anti-id) antibodies were investigated. Polyclonal rabbit anti-id antibodies and the corresponding rat anti-id Mabs were generated and characterized. Following immunizations in mice, antisera raised against anti-id antibodies were analyzed by typical immunoassays. It was observed that mouse anti-anti-id sera (Ab3) revealed binding affinity and specificity to CA215 that are comparable to those of RP215. Both RP215 and Ab3 were shown to induce apoptosis of cultured cancer cells in vitro by TUNEL and MTT assays. These experimental observations were consistent with that of in vivo tumor growth inhibition by RP215 in previous nude mouse experiments. Therefore, heterologous or homologous anti-id antibodies of RP215 that contain the internal image of its specific epitope in CA215 may serve as effective anti-cancer vaccines for therapeutic treatments of various cancers in humans. The relative stability of RP215-specific carbohydrate-associated epitope was compared to that of human IgG at extreme pH's (<or=2 or >or=12) or following NaIO(4) treatments. The major molecular forms of CA215 were further documented with various enzyme immunoassays and found to have similar secondary structures to those of normal human immunoglobulin G.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.