ReviewCurrent opinion in clinical nutrition and metabolic care2010
Genetics of type 2 diabetes.
Review in Current opinion in clinical nutrition and metabolic care, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Disrupted renal clock and blood pressure rhythms in type 2 diabetic nephropathy.Clinical science (London, England : 1979) · 2026Article
- Diabetes-associated Genetic Variation inJournal of the Endocrine Society · 2024Article
- Multi-level exploration of auricular acupuncture: from traditional Chinese medicine theory to modern medical application.Frontiers in neuroscience · 2024Review
- TheFrontiers in endocrinology · 2024Article
- The melatonin receptor 1B gene links circadian rhythms and type 2 diabetes mellitus: an evolutionary story.Annals of medicine · 2023Review
- Comprehensive analysis of endoplasmic reticulum stress-related mechanisms in type 2 diabetes mellitus.World journal of diabetes · 2023Article
- Molecular Genetics of Abnormal Redox Homeostasis in Type 2 Diabetes Mellitus.International journal of molecular sciences · 2023Review
- Differential contribution of alpha and beta cell dysfunction to impaired fasting glucose and impaired glucose tolerance.Diabetologia · 2023Article
- It's What and When You Eat: An Overview of Transcriptional and Epigenetic Responses to Dietary Perturbations in Pancreatic Islets.Frontiers in endocrinology · 2022Review
- Limitations of the fasting proinsulin to insulin ratio as a measure of β-cell health in people with and without impaired glucose tolerance.European journal of clinical investigation · 2021Article
- Circadian Etiology of Type 2 Diabetes Mellitus.Physiology (Bethesda, Md.) · 2018Review
- Development of diabetes does not alter behavioral and molecular circadian rhythms in a transgenic rat model of type 2 diabetes mellitus.American journal of physiology. Endocrinology and metabolism · 2017Article
- Effect of maternal PCOS and PCOS-like phenotype on the offspring's health.Molecular and cellular endocrinology · 2016Review
- Circadian variation of the pancreatic islet transcriptome.Physiological genomics · 2016Article
- The islet circadian clock: entrainment mechanisms, function and role in glucose homeostasis.Diabetes, obesity & metabolism · 2015Review
- Regenerative medicine in diabetes.Mayo Clinic proceedings · 2015Review
- Diabetes-associated common genetic variation and its association with GLP-1 concentrations and response to exogenous GLP-1.Diabetes · 2012Article
- A concerted decline in insulin secretion and action occurs across the spectrum of fasting and postchallenge glucose concentrations.Clinical endocrinology · 2012Article
- Resistance to type 2 diabetes mellitus: a matter of hormesis?Nature reviews. Endocrinology · 2011Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
purpose of reviewTo provide an overview of the genetics of type 2 diabetes in the context of recent progress in the understanding of the genetic architecture of the disease and its applicability to the pathogenesis of the disease as well as efforts to individualize therapy in type 2 diabetes. Efforts are underway to understand how these loci alter measurable physiologic processes in nondiabetic humans. However, it is important to understand the potential pitfalls in such studies and the limitations underlying measurement of insulin secretion and action using qualitative methodologies. RECENT
findingsThe availability of large population-based cohorts and the ease with which large numbers of common genetic variants can be genotyped has enabled the discovery of multiple loci and pathways associated with type 2 diabetes. Recent efforts examining quantitative traits such as fasting glucose concentrations have led to the discovery of other genes likely to be important in the development of diabetes. SUMMARY: The past 4 years have witnessed a significant increase in our understanding of genetic predisposition to type 2 diabetes. Hopefully more progress will be made in applying this knowledge to the pathophysiology of type 2 diabetes in the coming years.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.