ArticleJournal of bacteriology2010
Characterization of the replication, transfer, and plasmid/lytic phage cycle of the Streptomyces plasmid-phage pZL12.
Article in Journal of bacteriology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Coral mucus as a reservoir of bacteriophages targeting Vibrio pathogens.The ISME journal · 2024Article
- Protein-Mediated and RNA-Based Origins of Replication of Extrachromosomal Mycobacterial Prophages.mBio · 2020Article
- YMC-2011, a Temperate Phage of Streptococcus salivarius 57.I.Applied and environmental microbiology · 2017Article
- The complete 12 Mb genome and transcriptome of Nonomuraea gerenzanensis with new insights into its duplicated "magic" RNA polymerase.Scientific reports · 2016Article
- Function, expression, specificity, diversity and incompatibility of actinobacteriophage parABS systems.Molecular microbiology · 2016Article
- Identification and Characterization of a GeneFrontiers in cellular and infection microbiology · 2016Article
- The Streptomyces leeuwenhoekii genome: de novo sequencing and assembly in single contigs of the chromosome, circular plasmid pSLE1 and linear plasmid pSLE2.BMC genomics · 2015Article
- Identification of three extra-chromosomal replicons in Leptospira pathogenic strain and development of new shuttle vectors.BMC genomics · 2015Article
- Evolutionary relationships among actinophages and a putative adaptation for growth in Streptomyces spp.Journal of bacteriology · 2013Article
- Characterization of replication and conjugation of plasmid pWTY27 from a widely distributed Streptomyces species.BMC microbiology · 2012Article
- Fis is essential for the stability of linear plasmid pBSSB1 and affects the motility of Salmonella enterica serovar Typhi.PloS one · 2012Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report here the isolation and recombinational cloning of a large plasmid, pZL12, from endophytic Streptomyces sp. 9R-2. pZL12 comprises 90,435 bp, encoding 112 genes, 30 of which are organized in a large operon resembling bacteriophage genes. A replication locus (repA) and a conjugal transfer locus (traA-traC) were identified in pZL12. Surprisingly, the supernatant of a 9R-2 liquid culture containing partially purified phage particles infected 9R-2 cured of pZL12 (9R-2X) to form plaques, and a phage particle (phiZL12) was observed by transmission electron microscopy. Major structural proteins (capsid, portal, and tail) of phiZL12 virions were encoded by pZL12 genes. Like bacteriophage P1, linear phiZL12 DNA contained ends from a largely random pZL12 sequence. There was also a hot end sequence in linear phiZL12. phiZL12 virions efficiently infected only one host, 9R-2X, but failed to infect and form plaques in 18 other Streptomyces strains. Some 9R-2X spores rescued from lysis by infection of phiZL12 virions contained a circular pZL12 plasmid, completing a cycle comprising autonomous plasmid pZL12 and lytic phage phiZL12. These results confirm pZL12 as the first example of a plasmid-phage in Streptomyces.
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