Evidence map›Paper›PMID 20472000›Full record

ArticleBehavioural brain research2010

Exercise effects on motor and affective behavior and catecholamine neurochemistry in the MPTP-lesioned mouse.

Lori M Gorton, Marta G Vuckovic, Nina Vertelkina, Giselle M Petzinger, Michael W Jakowec, Ruth I Wood

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavioural brain research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Corticosterone level and central dopaminergic activity involved in agile and exploratory behaviours in formosan wood mice (Apodemus semotus).Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2018
    Article
  16. Article
  17. Physical exercise-induced fatigue: the role of serotonergic and dopaminergic systems.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017
    Review
  18. MPPMolecular neurobiology · 2017
    Article
  19. Motor learning in animal models of Parkinson's disease: Aberrant synaptic plasticity in the motor cortex.Movement disorders : official journal of the Movement Disorder Society · 2017
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lori M GortonDepartment of Cell and Neurobiology, Keck School of Medicine of the University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90033, USA.
Marta G Vuckovic
Nina Vertelkina
Giselle M Petzinger
Michael W Jakowec
Ruth I Wood

Funding

Glutamate-Dopamine Plasticity in Nigrostriatal Injury: Excerise Enhanced RecoveryR01NS044327 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JAKOWEC, MICHAEL WALTER, WALSH, JOHN P · 2002 to 2010
$1.8M
Anxiety, depression, and serotonergic dysregulation in Parkinson's DiseaseK18DC009125 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI WOOD, RUTH I. · 2007 to 2007
$176k
NIDCD NIH HHS DC009125NIDCD NIH HHS K18 DC009125NINDS NIH HHS NS44327NINDS NIH HHS R01 NS044327
6 · The paper itself

Abstract

This study used 1-methyl-4-phenyl-1,2,3,6,-tetrahydropyridine (MPTP) in mice to determine if exercise improves behavior and dopamine (DA) and serotonin (5HT) content. Male C57BL/6 mice received MPTP (4 x 20mg/kg) or saline. They remained sedentary or exercised by treadmill or voluntary running wheel for 6 weeks (n=8/group). Saline-treated mice ran significantly faster on running wheels (22.8+/-1.0m/min) than on treadmill (8.5+/-0.5m/min), and MPTP lesion did not reduce voluntary exercise (19.3+/-1.5m/min, p>0.05). There was a significant effect of both lesion and exercise on overall Rotarod performance (ORP): MPTP lesion reduced ORP, while treadmill exercise increased ORP vs sedentary mice (p<0.05). MPTP increased anxiety in the marble-burying test: sedentary lesioned mice buried more marbles (74.0+/-5.2%) than sedentary controls (34.8+/-11.8%, p<0.05). Conversely, exercise reduced anxiety on the elevated plus maze. Among saline-treated mice, those exposed to voluntary wheel-running showed an increased percent of open arm entries (49.8+/-3.5%, p<0.05) relative to sedentary controls (36.2+/-4.0%, p<0.05). Neither MPTP nor exercise altered symptoms of depression measured by sucrose preference or tail suspension. MPTP significantly reduced DA in striatum (in sedentary lesioned mice to 42.1+/-3.0% of saline controls), and lowered 5HT in amygdala and striatum (in sedentary lesioned mice to 86.1+/-4.1% and 66.5+/-8.2% of saline controls, respectively); exercise had no effect. Thus, exercise improves behavior in a model of DA depletion, without changes in DA or 5HT.

Indexed as

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsAnxietyBehavior, AnimalBrainCorticosteroneDepressionDisease Models, AnimalDopamineMaleMiceMice, Inbred C57BLMotor ActivityParkinson DiseasePhysical Conditioning, AnimalRotarod Performance Test1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineCorticosteroneDopamineSerotonin

Identifiers

PMID20472000
PMCPMC2902645

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.