Evidence map›Paper›PMID 20471996›Full record

ReviewAntiviral research2010

Antiviral strategies to control calicivirus infections.

Jacques Rohayem, Mirko Bergmann, Julia Gebhardt, Ernest Gould, Paul Tucker, Andrea Mattevi, Torsten Unge, Rolf Hilgenfeld, Johan Neyts

Abstract readReview
In one paragraph

Review in Antiviral research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Isolation and molecular characteristics of a recombinant feline calicivirus from Qingdao, China.Veterinary research forum : an international quarterly journal · 2023
    Article
  2. Strategies for managing marine disease.Ecological applications : a publication of the Ecological Society of America · 2022
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Current tools for norovirus drug discovery.Expert opinion on drug discovery · 2016
    Review
  12. Review
  13. Article
  14. Norovirus infection in immunocompromised hosts.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2014
    Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jacques RohayemThe Calicilab, Institute of Virology, Dresden University of Technology, Dresden, Germany. jacques.rohayem@tu-dresden.de
Mirko Bergmann
Julia Gebhardt
Ernest Gould
Paul Tucker
Andrea Mattevi
Torsten Unge
Rolf Hilgenfeld
Johan Neyts

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Caliciviridae are human or non-human pathogenic viruses with a high diversity. Some members of the Caliciviridae, i.e. human pathogenic norovirus or rabbit hemorrhagic disease virus (RHDV), are worldwide emerging pathogens. The norovirus is the major cause of viral gastroenteritis worldwide, accounting for about 85% of the outbreaks in Europe between 1995 and 2000. In the United States, 25 million cases of infection are reported each year. Since its emergence in 1984 as an agent of fatal hemorrhagic diseases in rabbits, RHDV has killed millions of rabbits and has been dispersed to all of the inhabitable continents. In view of their successful and apparently increasing emergence, the development of antiviral strategies to control infections due to these viral pathogens has now become an important issue in medicine and veterinary medicine. Antiviral strategies have to be based on an understanding of the epidemiology, transmission, clinical symptoms, viral replication and immunity to infection resulting from infection by these viruses. Here, we provide an overview of the mechanisms underlying calicivirus infection, focusing on the molecular aspects of replication in the host cell. Recent experimental data generated through an international collaboration on structural biology, virology and drug design within the European consortium VIZIER is also presented. Based on this analysis, we propose antiviral strategies that may significantly impact on the epidemiological characteristics of these highly successful viral pathogens.

Indexed as

Disease OutbreaksAnimalsAntiviral AgentsBiomedical ResearchCaliciviridaeCaliciviridae InfectionsDrug DesignEnzymesEuropeEuropean UnionHumansUnited StatesViral Nonstructural ProteinsVirus ReplicationAntiviral AgentsEnzymesViral Nonstructural Proteins

Identifiers

PMID20471996
PMCPMC7114105

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.