ReviewClinical psychology review2011
Sleep disturbance as transdiagnostic: consideration of neurobiological mechanisms.
Review in Clinical psychology review, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 252 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
252 citing papers in PubMed, 8 syntheses or guidelines pooled it, 591 citations in OpenAlex.
- Digital phenotyping for predicting relapse in psychiatric disorders: a systematic review of passive sensing approaches.BMC psychiatry · 2026Pooled it
- A systematic review of the prevalence of fatigue in common mental disorders (mood disorders, anxiety disorders, personality disorders, and trauma and stressor related disorders).BMC psychiatry · 2026Pooled it
- Boulevard of broken rhythms: A systematic review and meta-analysis on the relationship between sleep disturbances and suicidal behavior in bipolar disorder.European psychiatry : the journal of the Association of European Psychiatrists · 2025Pooled it
- Sleep disturbances in anorexia nervosa.European eating disorders review : the journal of the Eating Disorders Association · 2025Pooled it
- Prepulse inhibition deficit as a transdiagnostic process in neuropsychiatric disorders: a systematic review.BMC psychology · 2023Pooled it
- Systematic Review and Meta-analysis of Adolescent Cognitive-Behavioral Sleep Interventions.Clinical child and family psychology review · 2017Pooled it
- Insomnia as a Precipitating Factor in New Onset Mental Illness: a Systematic Review of Recent Findings.Current psychiatry reports · 2017Pooled it
- Examining the role of psychological factors in the relationship between sleep problems and suicide.Clinical psychology review · 2017Pooled it
- Examining fronto-limbic brain and sleep mechanisms of antidepressant effects in cognitive-behavioral therapy for insomnia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Trial
- Integration of sleep and emotion treatment: a randomized trial of transdiagnostic CBT for comorbid insomnia.BMC psychiatry · 2025Trial
- Comparative feasibility and preliminary efficacy of CBT for insomnia among adults seeking and not seeking addiction treatment.Journal of sleep research · 2024Trial
- Impact of sleep disruption on BDD symptoms and treatment response.Journal of affective disorders · 2024Trial
- Is improving sleep and circadian problems in adolescence a pathway to improved health? A mediation analysis.Journal of consulting and clinical psychology · 2019Trial
- Modifying the Impact of Eveningness Chronotype ("Night-Owls") in Youth: A Randomized Controlled Trial.Journal of the American Academy of Child and Adolescent Psychiatry · 2018Trial
- The effects of improving sleep on mental health (OASIS): a randomised controlled trial with mediation analysis.The lancet. Psychiatry · 2017Trial
- Trial
- Circadian rhythms in major depressive disorder: mechanistic insights and therapeutic frontiers.Annals of medicine · 2026Review
- Are DSM-5 and ICD-11 posttraumatic stress disorder measures assessing the same construct? Evidence from a Rasch-based analysis.Journal of traumatic stress · 2026Article
- Pre-Pandemic Emotion Regulation and Supportive Relationships as Protective Factors Across Development: Prospective Prediction of Mental Health During the COVID-19 Pandemic.Child psychiatry and human development · 2026Article
- Sleep as a psychiatric vital sign, not just a symptom.Dusunen adam : Bakirkoy Ruh ve Sinir Hastaliklari Hastanesi yayin organi · 2026Article
192 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Sleep disturbance is increasingly recognized as an important, but understudied, mechanism in the complex and multi-factorial causation of the symptoms and functional disability associated with psychiatric disorders. This review proposes that it is biologically plausible for sleep disturbance to be mechanistically transdiagnostic. More specifically, we propose that sleep disturbance is aetiologically linked to various forms of psychopathology through: its reciprocal relationship with emotion regulation and its shared/interacting neurobiological substrates in (a) genetics--genes known to be important in the generation and regulation of circadian rhythms have been linked to a range of disorders and (b) dopaminergic and serotonergic function--we review evidence for the interplay between these systems and sleep/circadian biology. The clinical implications include potentially powerful and inexpensive interventions including interventions targeting light exposure, dark exposure, the regulation of social rhythms and the reduction of anxiety. We also consider the possibility of developing a 'transdiagnostic' treatment; one treatment that would reduce sleep disturbance across psychiatric disorders.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.