ArticleMolecular immunology2010
The SNF2H chromatin remodeling enzyme has opposing effects on cytokine gene expression.
Article in Molecular immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- SMARCA5-mediated chromatin remodeling is required for germinal center formation.The Journal of experimental medicine · 2024Article
- The chromatin remodeler Snf2h is essential for oocyte meiotic cell cycle progression.Genes & development · 2020Article
- ISWI ATPase Smarca5 Regulates Differentiation of Thymocytes Undergoing β-Selection.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Transcriptional burst fraction and size dynamics during lens fiber cell differentiation and detailed insights into the denucleation process.The Journal of biological chemistry · 2018Article
- IL-10 transcription is negatively regulated by BAF180, a component of the SWI/SNF chromatin remodeling enzyme.BMC immunology · 2012Article
- ATP-dependent chromatin remodeling in T cells.Biochemistry and cell biology = Biochimie et biologie cellulaire · 2012Review
- The chromatin remodeler ISWI regulates the cellular response to hypoxia: role of FIH.Molecular biology of the cell · 2011Article
- NF-κB and BRG1 bind a distal regulatory element in the IL-3/GM-CSF locus.Molecular immunology · 2011Article
- Dynamic BRG1 recruitment during T helper differentiation and activation reveals distal regulatory elements.Molecular and cellular biology · 2011Article
- CHD5, a brain-specific paralog of Mi2 chromatin remodeling enzymes, regulates expression of neuronal genes.PloS one · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cytokine gene expression is a key control point in the function of the immune system. Cytokine gene regulation is linked to changes in chromatin structure; however, little is known about the remodeling enzymes mediating these changes. Here we investigated the role of the ATP-dependent chromatin remodeling enzyme SNF2H in mouse T cells; to date, SNF2H has not been investigated in T cells. We found that SNF2H repressed expression of IL-2 and other cytokines in activated cells. By contrast, SNF2H activated expression of IL-3. The ISWI components SNF2H and ACF1 bound to the tested loci, suggesting the regulation was direct. SNF2H decreased accessibility at some binding sites within the IL2 locus, and increased accessibility within some IL3 binding sites. The changes in gene expression positively correlated with accessibility changes, suggesting a simple model that accessibility enables transcription. We also found that loss of the ISWI ATPase SNF2H reduced binding to target genes and protein expression of ACF1, a binding partner for SNF2H, suggesting complex formation stabilized ACF1. Together, these findings reveal a direct role for SNF2H in both repression and activation of cytokine genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.