Evidence map›Paper›PMID 20471491›Full record

ReviewMutation research2010

DNA methylation and mutator genes in Escherichia coli K-12.

Martin G Marinus

Open access · greenAbstract readReview
In one paragraph

Review in Mutation research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
  2. Article
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  5. Review
  6. G3 (Bethesda, Md.) · 2020
    Article
  7. Article
  8. Article
  9. The response of Escherichia coli to the alkylating agents chloroacetaldehyde and styrene oxide.Mutation research. Genetic toxicology and environmental mutagenesis · 2019
    Article
  10. Article
  11. Article
  12. Article
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  14. Article
  15. Article
  16. Article
  17. Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Martin G MarinusDepartment of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA. Electronic address: martin.marinus@umassmed.edu.
University of Massachusetts Chan Medical School · US

Funding

DNA Mismatch and Double-Strand Break RepairR01GM063790 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MARINUS, MARTIN G. · 2002 to 2010
$2.6M
NIGMS NIH HHS GM 63790NIGMS NIH HHS R01 GM063790
6 · The paper itself

Abstract

Mutator strains of Escherichia coli have been used to define mechanisms that account for the high fidelity of chromosome duplication and chromosome stability. Mutant strains defective in post-replicative mismatch repair display a strong mutator phenotype consistent with a role for correction of mismatches arising from replication errors. Inactivation of the gene (dam) encoding DNA adenine methyltransferase results in a mutator phenotype consistent with a role for DNA methylation in strand discrimination during mismatch repair. This review gives a personal perspective on the discovery of dam mutants in E. coli and their relationship to mismatch repair and mutator phenotypes.

Indexed as

DNA MethylationGenes, BacterialMutationDNA, BacterialDNA Mismatch RepairEscherichia coliMethylnitronitrosoguanidineRecombination, GeneticSite-Specific DNA-Methyltransferase (Adenine-Specific)DNA, BacterialMethylnitronitrosoguanidineSite-Specific DNA-Methyltransferase (Adenine-Specific)

Identifiers

PMID20471491
PMCPMC2932865
OpenAlexW2107379165

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.