ReviewSeminars in immunology2010
Towards a molecular understanding of the differential signals regulating alphabeta/gammadelta T lineage choice.
Review in Seminars in immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Article
- Development of αβ and γδ T Cells in the Thymus and Methods of Analysis.International journal of molecular sciences · 2025Review
- HEB collaborates with TCR signaling to upregulatebioRxiv : the preprint server for biology · 2025Article
- E proteins control the development of NKγδT cells through their invariant T cell receptor.Nature communications · 2024Article
- Development of γδ T Cells: Soldiers on the Front Lines of Immune Battles.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Direct regulation of TCR rearrangement and expression by E proteins during early T cell development.WIREs mechanisms of disease · 2022Review
- Distinct and temporary-restricted epigenetic mechanisms regulate human αβ and γδ T cell development.Nature immunology · 2020Article
- Article
- Nodal EBV+ cytotoxic T-cell lymphoma: A literature review based on the 2017 WHO classification.Journal of clinical and experimental hematopathology : JCEH · 2020Review
- Control of Intra-Thymic αβ T Cell Selection and Maturation by H3K27 Methylation and Demethylation.Frontiers in immunology · 2019Review
- Rpl22 Loss Selectively Impairs αβ T Cell Development by Dysregulating Endoplasmic Reticulum Stress Signaling.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Article
- The TCR ligand-inducible expression of CD73 marks γδ lineage commitment and a metastable intermediate in effector specification.The Journal of experimental medicine · 2014Article
- A novel T cell subset with trans-rearranged Vγ-Cβ TCRs shows Vβ expression is dispensable for lineage choice and MHC restriction.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Transcriptional control of CD4 and CD8 coreceptor expression during T cell development.Cellular and molecular life sciences : CMLS · 2013Review
- Combined deletion of Id2 and Id3 genes reveals multiple roles for E proteins in invariant NKT cell development and expansion.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- In vivo fate mapping identifies pre-TCRα expression as an intra- and extrathymic, but not prethymic, marker of T lymphopoiesis.The Journal of experimental medicine · 2013Article
- Control of hematopoietic stem cell emergence by antagonistic functions of ribosomal protein paralogs.Developmental cell · 2013Article
- Article
- The opposing roles of the transcription factor E2A and its antagonist Id3 that orchestrate and enforce the naive fate of T cells.Nature immunology · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
While insights into the molecular processes that specify adoption of the alphabeta and gammadelta fates are beginning to emerge, the basis for control of specification remains highly controversial. This review highlights the current models attempting to explain T lineage commitment. Recent observations support the hypothesis that the T cell receptor (TCR) provides instructive cues through differences in TCR signaling intensity and/or longevity. Accordingly, we review evidence addressing the importance of differences in signal strength/longevity, how signals differing in intensity/longevity may be generated, and finally how such signals modulate the activity of downstream effectors to promote the opposing developmental fates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.