ArticleJournal of the American Society for Mass Spectrometry2010
Imaging mass spectrometry with silver nanoparticles reveals the distribution of fatty acids in mouse retinal sections.
Article in Journal of the American Society for Mass Spectrometry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 110 citations in OpenAlex.
- MALDI Matrix: Origins, Innovations, and Frontiers.Chemical reviews · 2026Review
- Tissue derivatization for visualizing lactate and pyruvate in mouse testis tissues using matrix-assisted laser desorption/ionization-mass spectrometry imaging.Analytical and bioanalytical chemistry · 2024Article
- Development of a Mass Spectrometry Imaging Method to Evaluate the Penetration of Moisturizing Components Coated on Surgical Gloves into Artificial Membranes.Mass spectrometry (Tokyo, Japan) · 2024Article
- Surface-assisted laser desorption/ionization mass spectrometry imaging: A review.Mass spectrometry reviews · 2022Review
- Organic matrix-free imaging mass spectrometry.BMB reports · 2020Review
- Nanoparticle-based surface assisted laser desorption ionization mass spectrometry: a review.Mikrochimica acta · 2019Article
- Metabolomic changes in the mouse retina after optic nerve injury.Scientific reports · 2018Article
- Stearate-to-palmitate ratio modulates endoplasmic reticulum stress and cell apoptosis in non-B non-C hepatoma cells.Cancer science · 2018Article
- Nanoparticle assisted laser desorption/ionization mass spectrometry for small molecule analytes.Mikrochimica acta · 2018Review
- Assessing the potential of sputtered gold nanolayers in mass spectrometry imaging for metabolomics applications.PloS one · 2018Article
- Distribution of Antisense Oligonucleotides in Rat Eyeballs Using MALDI Imaging Mass Spectrometry.Mass spectrometry (Tokyo, Japan) · 2018Article
- Label-free molecular imaging of the kidney.Kidney international · 2017Review
- Laser Desorption/Ionization Mass Spectrometric Imaging of Endogenous Lipids from Rat Brain Tissue Implanted with Silver Nanoparticles.Journal of the American Society for Mass Spectrometry · 2017Article
- 3D Mass Spectrometry Imaging Reveals a Very Heterogeneous Drug Distribution in Tumors.Scientific reports · 2016Article
- Intact lipid imaging of mouse brain samples: MALDI, nanoparticle-laser desorption ionization, and 40 keV argon cluster secondary ion mass spectrometry.Analytical and bioanalytical chemistry · 2016Article
- Mass spectrometry imaging of therapeutics from animal models to three-dimensional cell cultures.Analytical chemistry · 2015Review
- Lipid imaging within the normal rat kidney using silver nanoparticles by matrix-assisted laser desorption/ionization mass spectrometry.Kidney international · 2015Article
- High-resolution MALDI mass spectrometric imaging of lipids in the mammalian retina.Histochemistry and cell biology · 2015Article
- Spatial organization of lipids in the human retina and optic nerve by MALDI imaging mass spectrometry.Journal of lipid research · 2014Article
- Imaging of lipids in rat heart by MALDI-MS with silver nanoparticles.Analytical and bioanalytical chemistry · 2014Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A new approach to the visualization of fatty acids in mouse liver and retinal samples has been developed using silver nanoparticles (AgNPs) in nanoparticle-assisted laser desorption/ionization imaging mass spectrometry (nano-PALDI-IMS) in negative ion mode. So far, IMS analysis has concentrated on main cell components, such as cell membrane phospholipids and cytoskeletal peptides. AgNPs modified with alkylcarboxylate and alkylamine were used for nano-PALDI-IMS to identify fatty acids, such as stearic, oleic, linoleic, arachidonic, and eicosapentaenoic acids, as well as palmitic acid, in mouse liver sections; these fatty acids are not detected using 2,5-dihydroxybenzoic acid (DHB) as a matrix. The limit of detection for the determination of palmitic acid was 50 pmol using nano-PALDI-IMS. The nano-PALDI-IMS method is successfully applied to the reconstruction of the ion images of fatty acids in mouse liver sections. We verified the detection of fatty acids in liver tissue sections of mice by analyzing standard lipid samples, which showed that fatty acids were from free fatty acids and dissociated fatty acids from lipids when irradiated with a laser. Additionally, we applied the proposed method to the identification of fatty acids in mouse retinal tissue sections, which enabled us to learn the six-zonal distribution of fatty acids in different layers of the retina. We believe that the current approach using AgNPs in nano-PALDI-IMS could lead to a new strategy to analyze basic biological mechanisms and several diseases through the distribution of fatty acids.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.