ArticleCurrent biology : CB2010
Functional comparison of H1 histones in Xenopus reveals isoform-specific regulation by Cdk1 and RanGTP.
Article in Current biology : CB, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- The maternal-to-zygotic transition: reprogramming of the cytoplasm and nucleus.Nature reviews. Genetics · 2025Review
- In vivo assembly of complete eukaryotic nucleosomes and (H3-H4)-only non-canonical nucleosomal particles in the model bacterium Escherichia coli.Communications biology · 2024Article
- Monitoring the compaction of single DNA molecules inProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Development of a Novel Nonradioisotopic Assay and Cdc25B Overexpression Cell Lines for Use in Screening for Cdc25B Inhibitors.Yonsei medical journal · 2018Article
- Post-translational regulation of the maternal-to-zygotic transition.Cellular and molecular life sciences : CMLS · 2018Review
- Zygotic Genome Activation in Vertebrates.Developmental cell · 2017Review
- Shaping mitotic chromosomes: From classical concepts to molecular mechanisms.BioEssays : news and reviews in molecular, cellular and developmental biology · 2015Review
- Glutamylation of Nap1 modulates histone H1 dynamics and chromosome condensation in Xenopus.The Journal of cell biology · 2015Article
- Global absolute quantification reveals tight regulation of protein expression in single Xenopus eggs.Nucleic acids research · 2014Article
- Intranuclear DNA density affects chromosome condensation in metazoans.Molecular biology of the cell · 2013Article
- The cell cycle and pluripotency.The Biochemical journal · 2013Review
- Histone H1 compacts DNA under force and during chromatin assembly.Molecular biology of the cell · 2012Article
- The adenomatous polyposis coli protein contributes to normal compaction of mitotic chromatin.PloS one · 2012Article
- Mitotic chromosome size scaling in Xenopus.Cell cycle (Georgetown, Tex.) · 2011Article
- Protein kinase A-mediated serine 35 phosphorylation dissociates histone H1.4 from mitotic chromosome.The Journal of biological chemistry · 2011Article
- Article
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2 authors.
Funding
Abstract
H1 "linker" histones bind dynamically to nucleosomes and promote their compaction into chromatin fibers. Developmental H1 isoforms are evolutionarily conserved, but their function, regulation, and posttranslational modifications are poorly understood. In Xenopus egg extracts, the embryonic linker histone H1M does not affect nuclear assembly or replication but is required for proper chromosome architecture during mitosis. We report here that somatic H1 isoforms, which are more positively charged and feature multiple Cdk1 phosphorylation sites, cannot substitute for H1M at endogenous concentrations, instead causing chromatin compaction during interphase and dissociating from chromosomes at the onset of mitosis. Mitotic Cdk1 phosphorylation is not responsible for this dissociation and instead functions to enhance H1 binding in egg extracts and embryos. Nuclear import receptors RanBP7 and importin beta bind tightly to somatic H1 but not H1M, and addition of a constitutively active Ran mutant abolishes this interaction and enhances the ability of somatic H1 to rescue mitotic chromosome architecture. Our results reveal distinct regulatory mechanisms among linker histone isoforms and a specific role for H1M to compact chromosomes during egg meiotic arrest and early embryonic divisions.
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