Trial reportSchizophrenia research2010
Are cannabis use disorders associated with an earlier age at onset of psychosis? A study in first episode schizophrenia.
Trial report in Schizophrenia research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.
- Does Cannabis Use Contribute to Schizophrenia? A Causation Analysis Based on Epidemiological Evidence.Biomolecules · 2025Pooled it
- Clinical Effects of Cannabis Use in First-Episode Acute Psychotic Patients.Noro psikiyatri arsivi · 2023Article
- Self-Evisceration of Intestines as the Initial Presentation of Schizoaffective Disorder.Case reports in psychiatry · 2023Article
- A cross-sectional study of substance use in patients with schizophrenia hospitalized for relapse at the Ar-Razi Psychiatric Hospital in Salé, CHU Ibn Sina Rabat, Morocco.The Pan African medical journal · 2022Article
- Δ-9-Tetrahydrocannabinol treatment during adolescence and alterations in the inhibitory networks of the adult prefrontal cortex in mice subjected to perinatal NMDA receptor antagonist injection and to postweaning social isolation.Translational psychiatry · 2020Article
- Premorbid Adjustment and IQ in Patients With First-Episode Psychosis: A Multisite Case-Control Study of Their Relationship With Cannabis Use.Schizophrenia bulletin · 2020Article
- Factors Moderating the Association Between Cannabis Use and Psychosis Risk: A Systematic Review.Brain sciences · 2020Review
- Age of onset of substance use in patients with dual diagnosis and its association with clinical characteristics, risk behaviors, course, and outcome: A retrospective study.Indian journal of psychiatry · 2019Article
- Cannabis, a Significant Risk Factor for Violent Behavior in the Early Phase Psychosis. Two Patterns of Interaction of Factors Increase the Risk of Violent Behavior: Cannabis Use Disorder and Impulsivity; Cannabis Use Disorder, Lack of Insight and Treatment Adherence.Frontiers in psychiatry · 2018Article
- Prolonged cannabis withdrawal in young adults with lifetime psychiatric illness.Preventive medicine · 2017Article
- Auditory and non-auditory hallucinations in first-episode psychosis: Differential associations with diverse clinical features.Psychiatry research · 2017Article
- Cannabis and development of dual diagnoses: A literature review.The American journal of drug and alcohol abuse · 2017Review
- Concurrent and Sustained Cumulative Effects of Adolescent Marijuana Use on Subclinical Psychotic Symptoms.The American journal of psychiatry · 2016Article
- Cannabis use and cognitive function in first episode psychosis: differential effect of heavy use.Psychopharmacology · 2016Article
- Marijuana use in the immediate 5-year premorbid period is associated with increased risk of onset of schizophrenia and related psychotic disorders.Schizophrenia research · 2016Article
- The association between cannabis abuse and subsequent schizophrenia: a Swedish national co-relative control study.Psychological medicine · 2015Article
- The Cannabis Pathway to Non-Affective Psychosis may Reflect Less Neurobiological Vulnerability.Frontiers in psychiatry · 2014Article
- Treated incidence and baseline characteristics of substance induced psychosis in a Norwegian catchment area.BMC psychiatry · 2013Article
- Correlations between awareness of illness (insight) and history of addiction in heroin-addicted patients.Frontiers in psychiatry · 2012Article
Corrections and comments
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Authors and funding
9 authors at 7 institutions in 1 country.
Funding
Abstract
introductionThe purpose of this study is to determine if an earlier age at onset of positive symptoms in schizophrenia is associated with cannabis use disorders (CUD).
methods49 first-episode schizophrenia subjects with CUD were compared to 51 first-episode schizophrenia subjects with no substance use disorders for demographic and clinical variables. A multivariate logistic regression was performed to determine the joint relationship between variables significantly associated with CUD on univariate testing and ascertain if these variables independently predict CUD. Significance level was set at p<0.05.
results74% of CUD subjects had the onset of CUD before the onset of positive symptoms. Compared to non-substance abusing subjects, CUD subjects were predominantly male, younger at study entry, had an earlier age at onset of positive symptoms, less educational attainment, a lower self-socioeconomic status, better premorbid childhood social adjustment, a trend for poorer premorbid childhood academic adjustment, less motor abnormalities but more severe hallucinations and delusions. In the multivariate analysis, only male gender, worse socio-economic status, better premorbid childhood social adjustment, and more severe positive symptoms at study entry were associated with a lifetime history of CUD. DISCUSSION: Although cannabis use precedes the onset of illness in most patients, there was no significant association between onset of illness and CUD that was not accounted for by demographic and clinical variables. Previous studies implicating CUD in the onset of schizophrenia may need to more comprehensively assess the relationship between CUD and schizophrenia, and take into account additional variables that we found associated with CUD.
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