Evidence map›Paper›PMID 20471112›Full record

ArticleTrends in neurosciences2010

LINE-1 retrotransposons: mediators of somatic variation in neuronal genomes?

Tatjana Singer, Michael J McConnell, Maria C N Marchetto, Nicole G Coufal, Fred H Gage

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Trends in neurosciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 141 papers.

0numbers the graph read from it
0cells of the map it votes in
141citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

141 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Retrotransposons in embryogenesis and neurodevelopment.Biochemical Society transactions · 2024
    Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. CRISPR: A new paradigm of theranostics.Nanomedicine : nanotechnology, biology, and medicine · 2021
    Review
  18. Review
  19. Article
  20. Article

81 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tatjana SingerLaboratory of Genetics, Salk Institute for Biological Studies, La Jolla, California, USA.
Michael J McConnell
Maria C N Marchetto
Nicole G Coufal
Fred H Gage

Funding

L1 Retrotransposon and Neural DiversityR01MH088485 · NIMH · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI GAGE, FRED H · 2009 to 2012
$1.5M
NIMH NIH HHS MH088485NIMH NIH HHS R01 MH088485
6 · The paper itself

Abstract

LINE-1 (L1) elements are retrotransposons that insert extra copies of themselves throughout the genome using a 'copy and paste' mechanism. L1s comprise nearly approximately 20% of the human genome and are able to influence chromosome integrity and gene expression upon reinsertion. Recent studies show that L1 elements are active and 'jumping' during neuronal differentiation. New somatic L1 insertions could generate 'genomic plasticity' in neurons by causing variation in genomic DNA sequences and by altering the transcriptome of individual cells. Thus, L1-induced variation could affect neuronal plasticity and behavior. We discuss potential consequences of L1-induced neuronal diversity and propose that a mechanism for generating diversity in the brain could broaden the spectrum of behavioral phenotypes that can originate from any single genome.

Indexed as

BrainGenome, HumanHumansLong Interspersed Nucleotide ElementsNeurogenesisNeuronsRetroelementsRetroelements

Identifiers

PMID20471112
PMCPMC2916067

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.