Evidence map›Paper›PMID 20470871›Full record

ArticleBrain research bulletin2010

Nucleus accumbens lesions modulate the effects of methylphenidate.

Adam Podet, Min J Lee, Alan C Swann, Nachum Dafny

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain research bulletin, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 39 citations in OpenAlex.

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  14. Dorsal raphe neuronal activities are modulated by methylphenidate.Journal of neural transmission (Vienna, Austria : 1996) · 2013
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Adam PodetDepartment of Neurobiology and Anatomy, The University of Texas-Medical School at Houston, P.O. Box 20708, Houston, TX 77225, United States.
Min J Lee
Alan C Swann
Nachum Dafny

Funding

How and Where Methylphenidate Exerts Effect in Adolescent and Adult BrainsR01DA027222 · NIDA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DAFNY, NACHUM · 2009 to 2013
$1.5M
NIDA NIH HHS R01 DA027222
6 · The paper itself

Abstract

The psychostimulant methylphenidate (MPD, Ritalin) is the prescribed drug of choice for treatment of ADHD. In recent years, the diagnosis rate of ADHD has increased dramatically, as have the number of MPD prescriptions. Repeated exposure to psychostimulants produces behavioral sensitization in rats, an experimental indicator of a drug's potential liability. In studies on cocaine and amphetamine, this effect has been reported to involve the nucleus accumbens (NAc), one of the nuclei belonging to the motive circuit. The aim of this study was to investigate the role of the NAc on the expression of behavioral sensitization as a response to MPD exposure. In the present study, 20 male Sprague-Dawley rats were divided randomly into three groups: an intact control group, a sham-operated group, and a NAc bilateral electrical lesion group. Locomotor activity was assessed for the first 2h following 2.5mg/kg MPD injection, using open field monitoring systems. Recordings were made during 6 days of continuous MPD administration, and then upon re-challenge with the same dose following 3 days of washout. Acute MPD exposure elicited an increase in locomotor activity in all three groups. However, the NAc lesion group exhibited significantly increased locomotor activity in comparison to sham and control groups. Chronic MPD did not elicit sensitization in the NAc lesion group, while both sham and control groups did exhibit behavioral sensitization to repetitive MPD administration. These findings suggest that the NAc plays a significant role in eliciting locomotor activity as an acute effect of MPD, and in the expression of sensitization due to chronic MPD exposure.

Indexed as

Analysis of VarianceAnimalsCentral Nervous System StimulantsMaleMethylphenidateMotor ActivityNucleus AccumbensRatsRats, Sprague-DawleyStereotyped BehaviorTime FactorsCentral Nervous System StimulantsMethylphenidate

Identifiers

PMID20470871
PMCPMC3935495
OpenAlexW2068319999

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.